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| Changes and Clinical Significance of Serum MMP-9 Concentration in Patients with Acute Cerebral Infarction in Anterior and Posterior Circulation |
| ZHOU Dongliang, WANG Jianmin |
| Shanghai Baoshan District Renhe Hospital, Shanghai 200431, China |
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Abstract Objective: To explore the changes of serum matrix metalloproteinase-9 (MMP-9) concentration in patients with acute cerebral infarction in anterior and posterior circulation and its correlation with the severity of the disease. Method: A retrospective study was conducted in 88 patients with acute cerebral infarction who were admitted to the Department of Neurology, Shanghai Baoshan District Renhe Hospital from January 2013 to July 2018. There were 46 cases with anterior circulation infarction and 42 cases with posterior circulation infarction. According to the prognosis of the patients, they were divided into a death group (n=35) and a survival group (n=53). Meanwhile, 50 healthy people were selected as the control group. The level of MMP-9 was detected by ELISA, and the baseline data of patients were collected for statistical analysis. Result: The level of MMP-9 in cerebral infarction group was significantly higher than that in control group (P<0.05). The serum MMP-9 level in the anterior circulation group was significantly lower than that in the posterior circulation group, the difference was statistically significant (P<0.05). The NIHSS score in the anterior circulation group was (12.29±2.26), which was lower than (19.38±4.32) in the posterior circulation group, the difference was statistically significant (P<0.05). The NIHSS scores in the anterior circulation group and posterior circalation group were positive correlated with serum MMP-9 (r=0.651, 0.591, P<0.001). The proportion of smoking, drinking, lipid metabolism disorder, cerebral artery stenosis and posterior circulation acute cerebral infarction in the death group were significantly higher than those in the survival group, the level of MMP-9 was lower than that in the survival group, and the levels of WBC and hs-CRP were higher than those in the survival group (P<0.05). MMP-9, hs-CRP, WBC, acute cerebral infarction in posterior circulation, lipid metabolism disorder, drinking history and cerebral artery stenosis were all independent risk factors that affect the prognosis of patients (P<0.05). Conclusion: The level of MMP-9 in patients with acute cerebral infarction is significantly increased, which is positive correlated with the NIHSS scores. The level of serum MMP-9 in patients with acute cerebral infarction in posterior circulation is higher than that in patients with acute cerebral infarction in anterior circulation, and the level of MMP-9 is a prognostic factor.
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Received: 28 September 2022
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