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| Study on Correlation and Predictive Value between Mild Cognitive Disorder of Cerebral Vascular Disease and Plasma Asymmetric Dimethylarginine and Homocysteine |
| RUAN Hongqing, RUAN Honghua |
| Xinyu Mining Hospital, Xinyu 338000, China |
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Abstract Objective: To investigate the correlation between mild cognitive disorder of cerebral vascular disease and plasma asymmetric dimethylarginine (ADMA) and homocysteine (Hcy). Method: A prospective study was used in this study. A total of 120 patients diagnosed with cerebral vascular disease in Xinyu Mining Hospital from January 2017 to January 2021 were included in the study. Among them, 48 patients with cognitive disorder, all of them mild cognitive disorder, were included in the observation group, and 72 patients with normal cognition were included in the control group. The levels of ADMA and Hcy in patients were detected by enzyme-linked immunosorbent assay, and the differences between the two groups were compared, and the correlation between mild cognitive disorder and plasma ADMA and Hcy in patients with cerebral vascular disease was analyzed. Result: The MoCA score of the observation group was lower than that of the control group, and the levels of ADMA and Hcy were significantly higher than those of the control group (P<0.05). Through correlation analysis, there were negatively correlation between MoCA and ADMA, Hcy levels, and the sensitivity and accuracy of combined detection of ADMA and Hcy were significantly higher than those of single detection (P<0.05). Through ROC curve analysis, the area under the curve of joint detection was significantly higher than that of single detection (P<0.05), and the critical values of ADMA and Hcy levels in the observation group respectively was 0.68 μmol/L, 30.26 μmol/L. Conclusion: Mild cognitive disorder of cerebral vascular disease is significantly correlated with ADMA and Hcy, which can be used as an important diagnostic reference for cognitive impairment in the future.
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Received: 26 September 2022
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