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Abstract Objective：To analyze the epidemiologic data of acute pyelonephritis with pregnancy in Dongguan district.Method：483 patients of acute pyelonephritis with pregnancy were enrolled from January 2012 to December 2013.Morbidity of acute pyelonephritis with pregnancy， symptom and complication， spectrum of pathogen， tolerance，prognosis were investigated.Result：Morbidity of acute pyelonephritis with pregnancy was 3.13%，morbidity of acute pyelonephritis with pregnancy in 2013 for 3.69% was significantly higher than that in 2012 for 2.47%，the difference was statistically significant（P=0.000）.Symptom and complication included pyrexia>38.3 ℃ were 429 cases for 88.82%，anemia（hemoglobin<90 g/L）were 265 cases for 54.87%， acute kidney dysfunction（baseline creatinine increased 1.5 times）were 89 cases for 18.43% and electrolyte disorder were 58 cases for 12.01%.In 483 were a total of 392 urine cultures were positive，including bacillus were 229 cases accounted for 58.42%， coccus were 117 cases accounted for 29.85%， fungi were 46 cases accounted for 11.73%，the major pathogen were as follows：escherichia coli for 40.82%，
staphylococcus saprophyticus for 16.58%， klebsiella pneumonia for 11.22% and enterococcus faecalis for 8.16%.Morbidity of fungal infection in 2013 for 14.40% was significantly higher than that in 2012 for 7.04%， the difference was statistically significant（ P=0.044）.Detectable rate of candida tropicalis in 2013 for 8.00% was significantly higher than that in 2012 for 1.41%， the difference was statistically significant（P=0.013）.Escherichia coli， staphylococcus saprophyticus，klebsiella pneumonia were sensitive to common antibiotics.Pregnancy outcomes in patients with acute pyelonephritis
was better.Conclusion：Morbidity of acute pyelonephritis with pregnancy is high.We could pay more attention to fungal infection.
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