Abstract Objective: To discuss the effectiveness, safety on hemabate( romethamine) for prevention of postpartum hemorrhage of scar uterine vaginal delivery. Method: 90 scar uterus vaginal delivery patients were chosen in our hospital from 2010 July to 2013 July, and randomly divided into experimental group( 42 cases) and control group( 48 cases). In the experimental group, after delivery of fetusconventional they were given intramuscular injection of oxytocin and hemabate intramuscular injection, the control group at the same time was given motherwort needle intramuscular injection. Two hours and 24 hours postpartum hemorrhage, the incidence of postpartum hemorrhage, the incidence of adverse drug reactions of two groups were compared. Result: The experimental group and control group of 2 hours postpartum hemorrhage 24 hours postpartum hemorrhage, the incidence of postpartum hemorrhage the experimental group were all less than those of the control group, there were significant differences between the two groups( P<0.05). The incidence of adverse reaction in the experimental group and the control group was 4.8% and 2.1%, there was no significant difference between the two groups.Conclusion: Hemabate for prevention of postpartum hemorrhage of scar uterine vaginal delivery is more obvious curative effect and less side reaction than motherwort needle.