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| Research of Correlation between Peripheral Blood Neutrophil/Lymphocyte Ratio and Renal Injury in Patients with Type 2 Diabetic Nephropathy and Its Early Diagnosis Efficiency |
| ZHONG Hongwen, ZHU Likang, XIE Xiping, TANG Ji, XIE Lihui, GE Ziqiang, LIU Rangwan |
| First-author's address: Ganxian District People's Hospital, Ganzhou City, Jiangxi Province, Ganzhou 341100, China |
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Abstract Objective: To explore the correlation between peripheral blood neutrophil/lymphocyte ratio and renal injury in patients with type 2 diabetic nephropathy (T2DN) and its early diagnosis efficiency. Method: The study subjects were selected from 70 patients with type 2 diabetes mellitus (T2DM) and 130 patients with T2DN who were hospitalized in the Endocrinology Department of Ganxian District People's Hospital, Ganzhou City from June 2021 to March 2022. Patients with T2DM were included in group C. According to the urine albumin creatine ratio (UACR), patients with T2DN were divided into group A and group B, with 65 cases in each group, and 105 healthy people in our hospital served as group D in the same period. The expression situation of neutrophil/lymphocyte ratio (NLR), glycosylated hemoglobin (HbA1c), creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), cystatin C (Cys C) and homocysteine (Hcy) were observe in the four groups, and the correlation between NLR and other indexes and its early diagnosis efficiency of T2DN were analyzed. Result: There were significant differences in NLR, HbA1c and Hcy among all groups (P<0.05), and the NLR, HbA1c, Hcy, Cr, BUN, and UA in group A, B and C were significantly higher than those in group D, Cys C and Hcy in group A and B were significantly higher than those in group C, and the NLR in group A was significantly higher than that in group B and C, the differences were statistically significant (P<0.05). There were significant differences in Cr, BUN and UA among all groups (P<0.05), and Cr, BUN and UA in group A and B were significantly higher than those in group C, and Cr, BUN and UA in group A were significantly higher than those in group B (P<0.05). Pearson correlation analysis showed that NLR had a strong correlation with Cr, BUN, and UA, and a certain correlation with Cys C (P<0.05). The ROC curve shows that when NLR 2.625, the maximum area under the curve obtained, with sensitivity=88.50%, specificity=84.30% and AUC=0.590. Conclusion: NLR in patients with T2DM showed an increasing trend, and the expression of NLR increased continuously with the progress of the disease in patients with T2DN, and it shows a correlation with renal function related indicators. NLR shows certain value in the auxiliary diagnosis and prognosis of patients with T2DN.
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Received: 22 December 2022
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