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| Efficacy of Famciclovir in the Prevention of Multiple Myeloma Complicated with Herpes Zoster and Its Effect on Cytokines IL-2 and IL-10 |
| XIE Shuiling, LAI Wenhong, XU Xi, LIU Liping, LIAO Changfeng, LI Hailiang |
| First-author's address: First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China |
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Abstract Objective: To investigate the efficacy of Famciclovir in the prevention of herpes zoster in multiple information myeloma and its effect on cytokines interleukin-2 (IL-2) and interleukin-10 (IL-10). Method: A total of 60 patients with multiple myeloma admitted to First Affiliated Hospital of Gannan Medical University from February 2020 to February 2021 were retrospectively selected and divided into observation group and control group according to the treatment methods, with 30 cases in each group. The control group received Bortezomib combined with Cyclophosphamide and Dexamethasone (BCD) regimen chemotherapy, while the observation group received Famciclovir orally on the basis of the control group. The adverse reactions, incidence of herpes zoster during chemotherapy, laboratory indicators, pain degree, clinical efficacy and satisfaction of the two groups were statistically analyzed. Result: The rate of adverse reactions during chemotherapy in the observation group was 10.00% (3/30), which was lower than 33.33% (10/30) in the control group (P<0.05); the incidence of herpes zoster was 3.33% (1/30), which was lower than 20.00% (6/30) in the control group (P<0.05). After treatment, the level of IL-10 in the observation group was lower than that in the control group (P<0.05), and the level of IL-2 in the observation group was higher than that in the control group (P<0.05). After treatment, the VAS score of the observation group was lower than that in the control group (P<0.05). There was no significant difference in clinical efficacy between the two groups (P>0.05). The satisfaction of patients in the observation group was 93.33%, which was higher than 66.67% in the control group (P<0.05). Conclusion: Famciclovir can effectively reduce the incidence of herpes zoster during the treatment of multiple myeloma, and effectively increase the level of cytokine IL-2 and reduce the level of IL-10.
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Received: 30 November 2022
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