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| Study on the Correlation between Complications and Clinical Indicators in Patients with End-stage Renal Disease with Different Traditional Chinese Medicine Constitutions |
| XIE Libiao, ZHANG Yanyu, ZENG Sheng, LIU Fenxiang, LI Yijun |
| First-author's address: Meizhou Second Hospital of Traditional Chinese Medicine, Guangdong Province, Meizhou 514000, China |
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Abstract Objective: To explore the correlation between complications and clinical indicators in patients with end-stage renal disease with different traditional Chinese medicine constitutions. Method: A total of 90 patients with end-stage renal disease who met the requirements in the Hemodialysis Room and the First Department of Meizhou Second Hospital of Traditional Chinese Medicine from December 2020 to December 2022 were retrospectively selected as the study objects. The distribution of three TCM constitutions of patients with end-stage renal disease, including Yang-deficiency, blood-stasis and phlegm-dampness were analyzed, and the incidence of complications in patients with Yang-deficiency, blood-stasis and phlegm-dampness as well as the correlation of clinical indicators were studied. Result: After syndrome differentiation of 90 patients with end-stage renal disease, the proportions of Yang deficiency type, blood stasis type and phlegm dampness type were higher, with 23 cases (25.56%) of Yang-deficiency type, 22 cases (24.44%) of blood-stasis type and 15 cases (16.67%) of phlegm-dampness type. There were significant differences in the levels of urea nitrogen (BUN), creatinine (Scr), hemog lobin (Hb), albumin (ALB), blood phosphorus (P), blood calcium (Ca), blood potassium (K) and the incidence of complications in patients with Yang-deficiency, blood stasis and phlegm-dampness (P<0.05). The BUN, Scr, Hb and ALB of phlegm-dampness type were significantly higher than those of Yang-deficiency type, and BUN, Hb and ALB were significantly higher than those of blood-stasis type (P<0.05). BUN, Scr, Hb and ALB in blood-stasis type were significantly higher than those in Yang-deficiency type (P<0.05). P, Ca and K of blood-stasis type were higher than those of phlegm-dampness type and Yang-deficiency type (P<0.05). The incidences of skin pruritus and infection in patients with phlegm-dampness type were higher than those in patients with Yang-deficiency type and blood-stasis type (P<0.05), and the incidence of heart dysfunction, metabolic disorder and anemia in patients with blood-stasis type were higher than those in patients with phlegm-dampness type (P<0.05). Patients with Yang-deficiency, blood-stasis and phlegm-dampness type were positively correlated with BUN clinical indicators, and the difference was statistically significant (P<0.05). Conclusion: The proportions of ESRD patients with constitution of Yang-deficiency type, blood-stasis type, phlegm-dampness type are high, the weight is important. There are significant differences in clinical indicators between different constitutions, and the level of toxin in patients with phlegm-dampness constitution is high which are prone to complications such as skin pruritus and infection. It is suggested to strengthen dialysis and reduce toxin levels as far as possible. The nutritional status of patients with Yang-deficiency and blood-stasis type is not as good as that of phlegm-dampness type. Attention should be paid to strengthening nutritional support treatment in the treatment to improve the quality of life.
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Received: 09 December 2022
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