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| Evaluation of Effect of Intestinal Flora Transplantation Intervention on Children with Autism and Gastrointestinal Symptoms |
| ZENG Kaidan, WEN Xuefeng, WANG Guilian |
| First-author's address: Yichun People's Hospital, Jiangxi Province, Yichun 336000, China |
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Abstract Objective: To explore the clinical efficacy of intestinal flora transplantation intervention on children with autism complicated with gastrointestinal symptoms. Method: A total of 80 children with autism and gastrointestinal symptoms admitted to Yichun People's Hospital from January 2022 to July 2022 were enrolled as the subjects. According to admission sequence, the children were divided into observation group and control group by the random number table method, with 40 cases in each group. The control group received routine rehabilitation training, and the observation group was given intestinal flora transplantation intervention on this basis. The efficacy, gastrointestinal symptoms [gastrointestinal symptom rating scale (GSRS)], autism symptoms [childhood autism rating scale (CARS), autism behavior checklist (ABC)], intestinal flora status (abundance of flora phylum) and adverse reactions were compared between the two groups. Result: The effective rates at 1 month and 2, 3, 6 months in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). After 1 month and 2, 3, 6 months of treatment, the total scores of GSRS, CARS and ABC in the observation group were better than those in the control group, the differences were statistically significant (P<0.05). After 1 month of treatment, the richness of firmicutes in the observation group was higher than that in the control group, with statistical significance (P<0.05), while there were no statistical significance in the abundance of other phyla between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions within 6 months between the two groups (P>0.05). Conclusion: Intestinal flora transplantation intervention has a significant efficacy in the treatment of children with autism and gastrointestinal symptoms. It can improve autism and gastrointestinal symptoms in children by regulating and restoring intestinal microbial balance.
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Received: 17 April 2023
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