|
Abstract Objective: To investigate the value of less invasive surfactant administration (LISA) in the treatment of neonatal respiratory distress syndrome (NRDS). Method: A total of 80 children with NRDS admitted to Jingdezhen Maternal and Child Health Hospital from May 2019 to August 2022 were selected and divided into the traditional group and the LISA group with 40 cases in each group according to random number table method. The traditional group was treated with endotracheal intubation, pulmonary surfactant (PS) perfusion and extubation (INSURE), while the LISA group was treated with LISA technology. Mechanical ventilation time, oxygen inhalation time, hospital stay and PS dosage were recorded in the two groups. The arterial partial pressure of carbon dioxide (PaCO2), oxygenation index (OI), partial oxygen pressure (PaO2), oxygen saturation (SaO2), pulmonary vascular resistance (PVR), extra vascular lung water (EVLW), mean pulmonary artery pressure (mPAP), right ventricular stroke work index (RVSWI) and serum advanced oxidation protein products (AOPPs), 8-hydroxydeoxyguanylate (8-OHdG) levels were compared between the two groups before and after administration. Adverse reactions and complications were recorded. Result: The duration of mechanical ventilation and hospital stay in the LISA group were shorter than those in the traditional group, and the dose of PS in the LISA group was lower than that in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of PaCO2 in two groups were lower than those before administration, the levels of PaO2, SaO2 and OI were higher than those before administration, and the level of PaCO2 in the LISA group was lower than that in the traditional group, the levels of PaO2, SaO2 and OI were higher than those in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of PVR, EVLW and mPAP in two groups were lower than those before administration, and the level of RVSWI in two groups were higher than those before administration, the levels of PVR, EVLW and mPAP in the LISA group were lower than those in the traditional group, and the level of RVSWI was higher than that in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of serum AOPPs and 8-OHdG in the two groups were lower than those before administration, the LISA group were lower than those in the traditional group, the differences were statistically significant (P<0.05). The percentages of bradycardia, mechanical ventilation and re-administration of PS in LISA group were 5.00%, 12.50% and 30.00%, which were lower than 20.00%, 32.50% and 52.50% in traditional group, the differences were statistically significant (P<0.05). Conclusion: LISA technology can improve the oxygenation function and pulmonary circulation function in children with NRDS, reduce the incidence of bradycardia, mechanical ventilation and re-administration of PS, and regulate the levels of serum AOPPs and 8-OHdG.
|
|
Received: 17 April 2023
|
|
|
|
