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| Comparison of CT Images and Tumor Markers between Early and Middle Stage Small Cell Lung Cancer and Non-small Cell Lung Cancer |
| KONG Lingqin, CHEN Suyuan, LI Xichuan, SHEN Huihui |
| First-author's address: Tumor Hospital of Jining, Shandong Province, Jining 272007, China |
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Abstract Objective: To compare the early and middle stage (stage Ⅰ-Ⅱ) small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), and to explore the potential typing basis and differential diagnosis method of lung cancer. Method: A total of 90 cases of SCLC and 78 cases of NSCLC stage Ⅰ to stage Ⅱ confirmed by pathology in Tumor Hospital of Jining from January 2018 to December 2022 were retrospectively analyzed. The differences of CT image and 7 kinds of texture characteristic values between the two groups were compared, and the differences of tumor markers [carcinoembryonic antigen (CEA), neuron specific enolase (NSE), cytokeratin 19 fragment (CYFRA21-1)] were compared between the two groups. Result: A total of 168 patients were enrolled in this study. The imaging data of SCLC group showed that it mainly originated from central airway and grew along bronchial submucosa, forming spindle like and branched nodular lesions. The gray test result of the SCLC group was higher than that of the NSCLC group (P<0.05), while the entropy, entropy and entropy difference of the NSCLC group were higher than those of the SCLC group (P<0.05). CEA level in SCLC group was significantly higher than that in NSCLC group (P<0.05); the CYFRA21-1 level in NSCLC group was higher than that in SCLC group (P<0.05). Conclusion: There are some significant differences between SCLC and NSCLC in CT morphology, texture analysis and specific tumor markers, which can be used as a reliable basis for early classification and an effective method for differential diagnosis.
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Received: 19 April 2023
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