|
|
|
| Effect of Pingchong Jiangni Tongluo Decoction Combined with Letrozol on Gonadal Hormone and Ovarian Function in Patients with Endometriosis |
| LIU Yuling, FANG Jia, CHEN Jiaojie, LIANG Ruining, YUAN Ziwen, LI Jiaxue |
| First-author's address: The Affiliated Hospital of Jiangxi University Chinese Medicine, Nanchang 330006, China |
|
|
|
|
Abstract Objective: To study the value of Pingchong Jiangni Tongluo Decoction + Letrozol in the treatment of endometriosis. Method: A total of 80 patients with endometriosis admitted to the Affiliated Hospital of Jiangxi University Chinese Medicine from August 2021 to May 2022 were selected and divided into groups by simple random distribution method, with 40 cases in each group. The study group was treated with Pingchong Jiangni Tongluo Decoction + Letrozol, and the control group was treated with Letrozol. The total effective rate, luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone (P), estradiol (E2), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-1β (IL-1β), interleukin-6 (IL-6), T lymphocyte (CD4+, CD3+, CD8+, CD4+/CD8+), ovarian volume, antral follicle count, TCM symptoms scores in the two groups were observed. Result: The total effective rate of the study group (92.50%) was higher than that of the control group (75.00%), the difference was statistically significant (P<0.05). There were no significant differences in gonadal hormone levels between the two groups before treatment (P>0.05); LH, FSH, P and E2 in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in inflammatory indexes between the two groups before treatment (P>0.05); the levels of TNF-α, IL-8, IL-1β and IL-6 in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in ovarian function between the two groups before treatment (P>0.05); the ovarian volume and the antral follicle count in the study group were better than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in TCM symptoms scores between the two groups before treatment (P>0.05); the scores of TCM symptoms in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in immune indexes between the two groups before treatment (P>0.05); CD4+, CD3+ and CD4+/CD8+ in the study group were higher than those in the control group, CD8+ was lower than that of control group, the differences were statistically significant (P<0.05). Conclusion: The therapeutic effect of Pingchong Jiangni Tongluo Decoction + Letrozol is more ideal, which can effectively improve gonadal hormone and ovarian function, reduce inflammatory reaction, and at the same time quickly relieve related symptoms and regulate patients' immune function.
|
|
Received: 17 April 2023
|
|
|
|
|
|
|
