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| Changes of Serum Hepatic Fibrosis and Ferritin Levels in Patients Non-alcoholic Fatty Liver Disease with Type 2 Diabetes Mellitus |
| LI Yingzi, SONG Qingchao, QI Xinyan |
| First-author's address: The Affiliated Tai’an City Central Hospital of Qingdao University, Tai’an 271000, China |
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Abstract Objective: To investigate the changes of serum indicators of hepatic fibrosis and ferritin levels in patients with non-alcoholic fatty liver disease (NAFLD) complicated with type 2 diabetes mellitus (T2DM) and their clinical significance. Method: A total of 88 patients with T2DM admitted to the Affiliated Tai’an City Central Hospital of Qingdao University from January 2021 to October 2022 were selected and divided into 31 patients in T2DM group (T2DM patients alone) and 57 patients in NAFLD group (NAFLD patients combined) according to the results of color Doppler ultrasound, and 32 healthy patients in the hospital during the same period were selected as control group. Serum indicators of hepatic fibrosis [collagen type Ⅳ (C-Ⅳ), hyaluronic acid (HA), laminin (LN)], and serum ferritin (SF) were compared among the three groups. According to the severity of NAFLD, patients in the NAFLD group were divided into 25 cases in the mild group (patients with mild NAFLD), 22 cases in the moderate group (patients with moderate NAFLD), and 10 cases in the severe group (patients with severe NAFLD). The correlation between hepatic fibrosis indexes and SF and the severity of NAFLD in patients with T2DM was determined. Result: Total cholesterol, triglyceride, LDL-C, fasting blood glucose and 2 h PG in T2DM group and NAFLD group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). HA in NAFLD group was significantly higher than that in control group, the difference was statistically significant (P<0.05). The level of SF in NAFLD group was higher than those in T2DM group and control group, and that in T2DM group was higher than that in control group, the differences were statistically significant (P<0.05). The levels of SF and HA in severe group and moderate group were significantly higher than those in mild group, the differences were statistically significant (P<0.05). Conclusion: In patients with T2DM complicated with NAFLD, there are abnormal expression of serum hepatic fibrosis indexes and SF levels, and with the aggravation of NAFLD, abnormal expression of fibrosis indexes and SF becomes more obvious.
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Received: 17 April 2023
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