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Abstract Objective: To investigate the relationship between microsatellite instability (MSI) status and pathological features in colorectal cancer tissues. Method: A retrospective study was carried out on 89 patients with colorectal cancer admitted to Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to January 2022. The microsatellite status of colorectal cancer tissue was detected by multiplex fluorescence polymerase chain reaction (PCR) method, the detection of MSI and microsatellite stable (MSS) status was detected, and the relationship between MSI and pathological characteristics of patients was analyzed. Result: Among 89 patients, MMR protein expression deletion rate was 38.20% (34/89), non-deletion rate was 61.80% (55/89), MSI accounted for 39.33% (35/89), and MSS accounted for 60.67% (54/89), Microsatellite status was correlated with the expression of MMR protein (P<0.05). MSI was correlated with age, tumor location, degree of differentiation, maximum tumor diameter, cancer nodules, lymph node metastasis and distant metastasis (P<0.05). Conclusion: MSI in colorectal cancer patients is not only related to age, but also has unique pathological characteristics, such as right colon, medium and low differentiation, large mass, no cancer nodules, no lymph node metastasis, no most patients with distant metastasis can provide reference for the evaluation of the disease.
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Received: 20 September 2022
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