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Abstract Objective：To observe the effect of insulin Determir combined with miglitol in treatment of secondary failure-to sulfonylureas in type 2 diabetes mellitus.Method：72 cases were randomly divided into group A and group B，36 cases of each group.The group A was treated with insulin Determir combined with Miglitol， while group B was given subcutaneous injection of insulin Aspart 30R.Both groups were treated for 12 weeks. The fasting plasma glucose（FBG），2-hour postprandial plasma glucose（2 h PG），glycosylated hemoglobin（HbAlc）， the control rate and incidence of low blood glucose before and after treatment of the two groups were compared.Result：After treatment， the FBG， 2 h PG and HbAlc of two groups were remarkably decreased，and the differences were statistically significant（P<0.05）. But there were no statistical significance between two groups after treatment（P>0.05）.And in the A group ，the rate of hypoglycemia was lower than in B group（P<0.05）.Conclusion：Insulin Determir combined with Miglitol is convenient，safe and effective with secondary failure of Sulphonylureas in type 2 diabetes mellitus.
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