Abstract Objective：To assess the potential protective effects of the novel melatonin agonist Neu-240 in the MPTP mouse model of Parkinson’s s disease.Method：Mice received daily injections of saline or MPTP（ 30 mg/kg） once perday for five consecutive days to induce Parkinsonism. Vehicle or Neu-240（ 0.1 or 3 mg/kg） once per day was administered（i.p.） once per day for 17 days， starting on the first day of MPTP injections. Open field test， pole test and traction test were
conducted on day 14， 15 and 17 after the first injections of MPTP， respectively.Result：Neu-240 at 3 mg/kg improvedbehavioral impairment induced by MPTP in the open field test and traction test but not in the pole test. Neu-240 at 0.1 mg/kgwas effective only in the open field test. Conclusion：The novel melatonin agonist Neu-240 exerts partial protective effects in the MPTP mouse model of Parkinson’s disease.
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