|
|
|
| Effect of Dexmedetomidine Combined with Subanesthetic Dose Esketamine Hydrochloride on Analgesia and Sedative Effects in Elderly Patients Undergoing Percutaneous Vertebroplasty |
| PENG Yue, OUYANG Kuanhong, WANG Rong, LIU Xi, YI Rong, DU Junqun |
| First-author's address: Pingxiang NO.2 People's Hospital, Jiangxi Province, Pingxiang 337000, China |
|
|
|
|
Abstract Objective: To investigate the effect of Dexmedetomidine combined with subanesthetic dose Esketamine Hydrochloride on analgesia and sedative effects in elderly patients undergoing percutaneous vertebroplasty. Method: A total of 102 elderly patients underwent percutaneous vertebroplasty admitted to Pingxiang NO.2 People's Hospital from February 2020 to February 2022 were selected as the study objects, and were divided into conventional group (n=51, Sufentanil + Dexmedetomidine) and observation group (n=51, Dexmedetomidine + subanesthetic dose Esketamine Hydrochloride) according to random number table method. Hemodynamics indexes [heart rate, mean arterial pressure (MAP), central venous pressure (CVP)], postoperative pain situation, incidence of restlessness and adverse reactions were compared between the two groups. Result: Induction of anesthesia (T1) and 2 min after operation (T2), MAP, heart rate and CVP of observation group were lower than those of conventional group, the differences were statistically significant (P<0.05). The restlessness degree of the observation group was lower than that of the conventional group, the difference was statistically significant (P<0.05). The Prince-Henry scores of the observation group at 9, 18 and 36 h after operation were lower than those of the conventional group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dexmedetomidine combined with subanesthetic dose Esketamine Hydrochloride in elderly patients undergoing percutaneous vertebroplasty can stabilize intraoperative hemodynamics, which is conducive to reducing the risk of restlessness, alleviating postoperative pain, and has good safety.
|
|
Received: 25 July 2023
|
|
|
|
|
|
|
