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| Analysis of the Expression and Significance of Ki-67 and P16 Protein in Cervical Cancer |
| WU Ying, SHI Jingjing, TU Jianhong |
| First-author's address: Nanchang Third Hospital, Nanchang 330000, China |
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Abstract Objective: To investigate the expression and significance of proliferating cell nuclear antigen-67 (Ki-67) and multiple tumor suppressor gene-16 (P16) protein in cervical cancer. Method: The clinical data of 70 patients who underwent cervical examination in Nanchang Third Hospital from July 2018 to August 2022 were analyzed retrospectively. All patients were diagnosed by pathological examination of cervical cancer and precancerous lesions. Among them, 39 patients with cervical cancer were enrolled in the cervical cancer group, and 31 patients [low-grade cervical intraepithelial neoplasia (CIN) with 13 cases and high-grade CIN with 18 cases] with precancerous lesions were enrolled in the precancerous lesions group. Ki-67 and P16 protein were detected by immunohistochemistry. The expression of Ki-67 and P16 protein in cervical cancer and precancerous lesions was analyzed, and the pathological results were used as the "gold standard" to analyze the diagnostic value of Ki-67 and P16 protein in cervical cancer. Result: The positive expression rates of Ki-67 and P16 protein in cervical cancer group were higher than those in low-grade CIN and high-grade CIN (P<0.05); the positive expression rates of CIN Ki-67 and P16 protein in high-grade were higher than those of low-grade CIN (P<0.05). There were no significant differences in sensitivity, specificity, accuracy, positive predictive value and negative predictive value between Ki-67 and P16 protein in the diagnosis of cervical cancer (P>0.05). Conclusion: Ki-67 and P16 protein have high positive expression rate in patients with cervical cancer, and they have similar value in the diagnosis of cervical cancer.
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Received: 09 January 2023
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