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| Study on the Correlation between Physical and Metabolic Indexes and Serum SIRT4 Levels in Obesity Children |
| WU Xian, YUAN Yi, YU Lirong, YANG Li, CHEN Ka, WU Jiali |
| First-author's address: Jiangxi Provincial Children's Hospital, Nanchang 330000, China |
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Abstract Objective: To analyze the correlation between physical and metabolic indexes and serum sirtuin-4 (SIRT4) levels in obesity children, and provide guidance for clinical treatment. Method: A total of 210 children with simple obesity diagnosed and treated in the Department of Endocrinology, Genetics and Metabolism of Jiangxi Provincial Children's Hospital from September 2020 to October 2022 were selected and divided into mild obesity group (n=74), moderate obesity group (n=121) and severe obesity group (n=15) according to body mass index (BMI). Physical indexes [BMI, waist circumference, hip circumference, waist-to-hip ratio (WHR) and skinfold thickness], glucose and lipid metabolism indexes [fasting blood glucose (FBG), insulin resistance index (HOMA-IR), total cholesterol (TC) and triacylglycerol (TG)], SIRT4 levels and growth hormone/insulin-like growth factor 1 (GH/IGF-1) were compared among the three groups. Pearson correlation was used to analyze the correlation between serum SIRT4 level and relevant physical and glucose and lipid metabolism indexes. ROC curve was used to analyze the predictive value of serum SIRT4 level to the degree of obesity in children. Result: There were no significant differences in age, gender, height, WHR, GH/IGF-1 and FBG among the three groups (P>0.05). There were statistically significant differences in physical indexes (BMI, waist circumference, hip circumference and skinfold thickness), glucose and lipid metabolism indexes (HOMA-IR, TC, TG) and serum SIRT4 levels among the three groups (P<0.05), and the levels of physical indexes and glucose and lipid metabolism indexes in the severely obesity group were the highest, while serum SIRT4 level was the lowest. Pearson correlation analysis results showed that the relevant physical indexes, glucose and lipid metabolism indexes were negatively correlated with serum SIRT4 level (P<0.05). ROC curve results showed that the AUC of serum SIRT4 level predicting the outcome of obesity (moderate to severe) was 0.763 (P<0.05). Conclusion: Physical indexes and glucose and lipid metabolism indexes of obesity children are negatively correlated with serum SIRT4 level, and serum SIRT4 level is correlated with the degree of obesity in children.
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Received: 19 July 2023
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