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| The Relationship Study of NF-κB with Early-onset and Late-onset Preeclampsia |
| The First Affiliated Hospital of Fujian Medical University，Fuzhou 350005，China |
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Abstract Objective： To explore the relationship of NF-κB in placenta with early-onset（ gestational age <32 weeks）and late-onset（gestational age ≥ 32 weeks）preeclampsia. Method：40 PE women were selected and divided into early-onset PE group of 20 cases and late-onset PE group of 20 cases.The normal control group were 30 healthy normotensive pregnancy.Immunohistochemistry was employed to show the location distribution and quantity of NF-κBp65 in placenta of preeclampsia. Result：NF–κBp65 in placenta of preeclampsia was stronger expression than that of control group，and was stronger expression in early-onset preeclampsia than that in late-onset preeclampsia，the differences were statistically significant（P<0.05）.Conclusion： It suggests that NF–κB participate in the pathogenesis of preeclampsia.Increasing NF–κB activity in placenta induces the immune inflammatory reaction，which may be related to the etiology of early-onset and late-onset preeclampsia.
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