Abstract Objective：Itching is a common symptom of dermatology， is the result of the interaction of multiplefactors， which by the central and peripheral mechanisms of dual control occur， but the exact mechanism is not clear.Withthe deepening of research in recent years， a variety of substances such as histamine， acetylcholine， serotonin， proteasesand protease-related receptors， cytokines， opioid peptides， and other media play an important role in the generation
process of pruritus， these media by stimulating type C nerve fibers or nerve fibers directly mediate receptor binding andskin feel itchy. Nerve conduction and conduction article will pruritus medium reviewed.
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