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| Influence of Buyanghuanwu Decoction on the Expression of TNF-ɑ，IL-6，CRP in Cerebral Ischemia Rats |
| Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine，Fuzhou 350003，China |
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Abstract Objective：To discuss the influence of Buyanghuanwu decoction on the expression of TNF-ɑ，IL-6，CRP in MCAO rats.Method：60 rats were divided into four groups：control group， model group，low-dose of Buyanghuanwu decoction group and high-dose of Buyanghuanwu decoction group.Motor nerve function of rat was evaluated by using Garcia JH score ，serum TNF-ɑ，IL-6 were detected by using bioluminescence and serum CRP were detected by using immunoturbidimetry.Result：7 days after surgery，compared with model group， nerve function of rats recovered in low-dose group and high-dose group，with significant difference（P<0.05）.There was significant difference between low-dose group and high-dose group（P<0.05）.Compared with model group，there was significant difference of TNF-ɑ in low-dose group and high-dose group（P<0.05）.Compared with model group，there was no difference of IL-6，CRP in low-dose group（P>0.05） ，with significant difference in high-dose group（P<0.05） .Conclusion：In order to protect nerve function，Buyanghuanwu decoction can reduce TNF-ɑ，IL-6，CRP and relieve inflammation.
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