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Abstract Objective：To investigate the prophylactic effect of antifungal therapy in patients with severe chronic obstructive pulmonary disease（COPD）. Method：140 patients with COPD in our hospital were divided into two groups randomly.The control group were received routine therapy， the observation group were given routine treatment combined with fluconazole therapy.The pulmonary fungal infection rate at different ages and different clinical scale of two groups were compared.Result：In patients at 70-80 ages， the fungal infection rates were 0（ 0/40） and 15.00%（6/40） in treatment group and control group respectively， with a significant difference between two groups（ P<0.05）.At very severe scale patients， the fungal infection rates of treatment group and control group were 0（ 0/36） and 15.38%（ 6/39） respectively，with a significant difference between two groups（ P<0.05）.Compared the fungal infection rates in patients at aged 60-70 （0 vs 2.50%） and at severe scale（ 0 vs 2.44%） of two groups， the differences were not statistically significant（P>0.05）. The incidence of adverse reactions between the two groups had no significant difference.Conclusion：Early application of antifungal treatment on COPD patients at 70-80 ages or at very severe clinical scale， has a preventive effect， and no obvious adverse reaction.
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