Abstract Objective： To explore and analyze CDK4， CDK2 and CDK1 gene in the hyperplastic scar fibroblasts，protein expression and the relationship with the cell cycle.Method： 40 of hyperplastic scar samples in our hospital wereselected from July 2012 to July 2014， according to the period of hyperplastic scar were divided into the 3 months group，the months group，the 1 year group and the 2 years group，each group with 10 specimens.10 normal specimens werecollected at the same time as a normal control group.The samples of CDK4， CDK2， CDK1 gene and their protein wereobserved and compared， at the same time the fibroblasts cycle were tested. Result： The content of CDK4， CDK2， CDK1gene and protein in the 3 months group，and 6 months group compared with the control group， the differences werestatistically significant（P<0.05）；the content of CDK4， CDK2， CDK1 gene and protein in the 6 months group，1 year
group， 2 years group compared with 3 months group，the differences were statistically significant（P<0.05）； the contentof CDK4， CDK2， CDK1 gene and protein in the 3 months group，1 year group，2 years group compared with 6 monthsgroup，the differences were statistically significant（P<0.05）.Early phase hyperplasia scar accounted for high percentageduring cell division cycle in S and G2/M phase，the result showed regulatory intervention with the related gene for the cellcycle can further develop hyperplastic scar effective inhibition effect. Conclusion： In different periods the trend of gene ofCDK4， CDK2， CDK1 and protein expression is broadly in line.The distribution of cell cycle corresponds the above threeprotein executive function each other， which provide reliable basis for clinical study.
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