|
|
|
| The Efficacy of Montelukast in Children with Allergic Purpura of Plasma Cytokines Levels |
| Zhanjiang Xiashan Maternity and Child Care， Zhanjiang 524013，China |
|
|
|
Abstract Objective：To study the clinical efficacy of montelukast in children with allergic purpura of plasma cytokine levels .Method： 100 children with allergic purpura were selected in our hospital as research subjects，and were randomly divided into two groups， the control group of children were given anti-histamine drugs， anti-infective drugs and calcium， vitamin C and other conventional drugs.The observation group was treated with montelukast chewable tablets treatment on the basis of conventional therapy. In two weeks for a course of treatment，the clinical effect of plasma cytokine levels in patients before and after treatment were compared and observed.Result： IL-6，IL-8 and TNF-α expression levels observed before the treatment，two groups of patients showed no significant difference（P>0.05）；after treatment， the expression levels of three indicators had decreased significantly，and compared with before the treatment， the differences were statistically significant（P<0.05）； observation group’ indicators decreased more than control group， the difference was statistically significant（P<0.05）.Observation group and control group of patients with clinical response rates were respectively 96.0% and 78.0%， the difference was statistically significant（P<0.05）.Conclusion：Montelukast treatment of children with allergic purpura have clinical efficacy， safety，and good benefits，
cytokines can be adjusted within the plasma of children， promote the improvement of immune function in children， worthy of clinical application.
|
|
|
|
|
|
|
|
|
