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| Protection of Pantoprazole with Fengliao Changweikang Capsule on Ethanol Damage Human Gastric Epithelial GES-1 Cells Injured by Ethanol |
| The People’s Hospital of Jiangmen，Jiangmen 529000，China |
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Abstract Objective：To Observe the protective effect of pantoprazole capsules with fengliao changweikang on human gastric epithelial GES-1 cells injured ethanol. Method： Human gastric epithelial GES-1 cells were cultured in vitro，incubated with different concentrations of ethanol，and observed at different time periods in order to establish a stable gastric mucosal injury model. Pantoprazole and fengliao changweikang capsules were formulated into different concentrations， MTT were used to observe the GES-1 cells intervention by two drugs alone and in combination.Result：Incubated at 7% ethanol for 3 h， human gastric epithelial GES-1 cells inhibition rate reached 40%， and this was the best model of injured gastric mucosal cell.Each concentration of pantoprazole and fengliao changweikang capsules had a protective effect on the GES-1 cells， the optimum concentration of both drugs were 60 μg/mL and 200 μg/mL， in combination with two drugs could reduce the dose and enhance the protective effect of the gastric mucosa. Conclusion：Combining with pantoprazole and fengliao changweikang capsules can improve medication safety， reduce the dosage， protect human gastric epithelial damage GES-1 cells at low doses，and they are worth promoting in clinical.
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