Abstract Objective：To assess the changes of energy metabolism and NF-κBp65 during spinal cord ischemiaand reperfusion injury（SCIRI）. Method：The SCIRI model was made by clamping the infrarenal aortic for 45 minutesin 40 rabbits.Reactive oxygen species（ROS），the expression of nuclear factor-kappa Bp65（NF-κBp65），inhibitor-Kappa Bα（I-κBα）， intercellular adhesion molecule（ICAM-1） and the content of adenine nucleotide（ADP，AMP
and ATP） in spinal cord tissue were determined before ischemia，45 minutes after ischemia，30，60 minutes and 120minutes after reperfusion. Result： The spinal cord content of adenine nucleotide and I-κBα decreased while ROS，theexpressions of NF-κBp65and ICAM-1 increased at 45 minutes after ischemia，30，60 minutes and 120 minutes afterreperfusion as compared to the value before ischemia（ P<0.01）. Conclusion：The upregulation of the expression ofICAM-1 and NF-κBp65 aggravates the energy metabolism disorder of spinal cord during SCIRI.
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