Abstract Objective：To observe the myocardial protective effect of the HTK solution in open heart operation for severe cardiac valve disease patients.Method：16 severe cardiac valve disease patients undergone open heart operation were received HTK solution for myocardial protection from April 2012 to March 2013， and their clinical data was compared with that of another 16 severe cardiac valve disease patients received cold blood cardioplegia for myocardial protection.
Result：The ratio of spontaneous cardiac rhythm recovery in the HTK solution group was higher than that of cold blood cardioplegia group（ P<0.05）.The average operation time， the cardiopulmonary bypass time， the aortic clamping time， the time from aorta declaming to heart rebeating， the assisted circulation time after aorta declaming， the mechanical ventilation support time， and the length-of-stay in ICU after operation in the HTK solution group were shorter than those of cold blood cardioplegia group（ P<0.05）.The dose of dopamine at the end of cardiopulmonary bypass was（ 5±2.5）μg/（kg·min），was less than that of cold blood cardioplegia group（ P<0.05）.The ratio of postoperative severe complications in the HTK solution group was also lower than that of cold blood cardioplegia group（ P<0.05）.The concentration of cTnI and CKMB was elevated after the onset of cardiopulmonary bypass， and the peak of cTnI and CKMB on the first postoperative day in two groups.The HTK solution group had lower cTnI and CKMB concentrations compared with cold blood cardioplegia group after cardiopulmonary bypass（ P ≤ 0.05）.Conclusion：The myocardial protective effect of the HTK solution in open heart operation for severe cardiac valve disease patients is better than that of cold blood cardioplegia.
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