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Abstract Objective： To investigate the diagnostic value of serum CEA， SCC and SF as analyzed with Logistic vegression and ROC curve in patients with lung cancer lymph nodes metastasis. Method： Serum CEA， SCC， and SF were detected in 100 patients with lung cancer， and in those cases， 65 cases were identified as lymph nodes metastasis group and 35 as non-metsatasis group. Result： The positive rate of CEA and SCC of metastais group was evidently higher than that of non-metastasis（ P<0.01，P<0.05）， but there was no significant difference for SF between the two groups. According to regression equation Y=1/[1+EXP（1.584X1+0.935X2-0.425）]， and the AUC of variable Y was higher than any of the three tumor markers. Conclusion： The combination of CEA and SCC is useful as indicator of lung cancer lymph nodes metastasis. Applications of Logistic regression and ROC curve increase diagnostic accuracy in lung cancer.
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