Abstract Objective：To compare the effect and safety of budesonide inhalation aerosol with intravenous glucocorticoids in the treatment of the acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Method： Totally 84 subjects with AECOPD were randomly divided into three groups. All patients were treated with budesonide inhalation aerosol， the intravenous methyl-prednisolone（IVM）， and the intravenous dexamethasone. Three
groups used 7 days therapy. The mMRC， blood gas analysis， pulmonary function and adverse reactions of three groups were observed.Result：The mMRC，blood gas analysis， and pulmonary function of three groups were significantly improved after treatment（P<0.05）.The group of budesonide inhalation aerosol was no significantly improved compared to intravenous methyl-prednisolone（IVM）（P>0.05）.The adverse reactions of budesonide inhalation aerosol group were significantly improved compared to intravenous methyl-prednisolone（IVM） group， and the intravenous dexamethasone
group（P<0.05）.Conclusion： The effect of Intravenous glucocorticoids treatment of the acute exacerbation of chronic obstructive pulmonary disease（AECOPD） is significant， there is no significant difference between budesonide inhalation aerosol group and intravenous methyl- prednisolone（IVM） group， but significantly improved than intravenous dexamethasone.At the same time，the adverse reactions of budesonide inhalation aerosol were less than intravenous glucocorticoids.So budesonide inhalation aerosol can be as another method to treat AECOPD，worthy of clinical application.
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