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Abstract Objective：To explore the therapeutic effect of valsartan combination treatment with mycophenolate mofetil and prednison in refractory nephropathy syndrome. Method：54 patients with primary refractory nephropathy syndrome were randomly divided into treatment group and control group. 36 cases of treatment group were treated by valsartan combined with MMF and prednisone， and 18 cases of the control groups were only threated with MMF and prednisone.The blood test， 24 h quantitation of proteinuria， liver function and renal function periodically were observed. Result：3 months later，the total effective rate were 94.5% and 83.3% respectively. Conclusion： Valsartan combined with MMF and prednisone is effective on child primary refractory nephropathy syndrome．It is a kind of promising clinical treatment of this disease at present
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