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Abstract Objective： To explore and analyze the integration of electroencephalogram（ EEG） amplitude， CDI，MRI in the diagnosis of premature infant brain injury research， aiming at a premature infant brain injury to provide reliable clinical diagnosis.Method：120 premature infants treated in our hospital of pediatrics from August 2012 to August 2012 were selected， they were all tested by EEG， CDI，and MRI， and the test results were recorded.Result：the amplitude of integration of EEG examination results： this group of premature infants with 48 cases formed discontinuous low voltage or pathological type graphics， positive rate was 40.00%（ 48/120）， and failed to detect the mature CY. CDI examination results： this group of 33 cases of patients with intracranial found positive lesions， positive rate was 27.50%（ 33/120），including 15 cases of premature infants diagnosed with intraventricular hemorrhage， accounted for 45.45%（ 15/33）， and 18 cases of premature infants diagnosed with hypoxia ischemic change， accounted for 54.55%（ 18/33）. MRI results： the group with 62 cases in preterm infants found positive in intracranial lesions， whose rate was 51.67%（ 62/120）， including 34 cases diagnosed with the brain ischemia， 19 cases diagnosed parenchymal dotted hemorrhage， accounted for 30.66% （19/62）， 9 cases diagnosed with the brain ischemia combined subarachnoid hemorrhage， accounted for 14.52%（ 9/62）. Conclusion：The accuracy and sensitivity of MRI diagnosis for premature infants is obviously higher than that of amplitude integration of electroencephalogram（ EEG） and CDI. electroencephalogram（ EEG） to the integration of these amplitude can be premature abnormal changes of sleep-wake cycle for diagnosis， and served as first diagnosis and follow-up tracking method applied in the clinical work.
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