Abstract Objective：To study the clinical effect of the intensive therapy with insulin pump and subcutaneous insulin infusion in treating incipient type 2 diabetes.Method：120 patients with incipient type 2 diabetes were randomly divided into two groups， 58 in Group A（ insulin pump intensive therapy） and 62 in Group B（ subcutaneous insulin infusion intensive therapy）.Changes of fasting blood glucose（ FBG）， BG 2 hours after meal（ PBG2 h）， glycosylated emoglobin（ HBA1C）， fasting C-peptide（C-P） and C-P 2hrs after meal were observed， and the time of BG to target，insulin dosage， and the frequency of hypoglycaemia before and after treatment， 2 weeks and 6 months after treatment were also observed.Result：After treatment， FBG， BG 2 hrs after meal and HBA1C were lower for the patients in both groups （P<0.05）， while fasting C-P、C-P 2 h were elevated（ P<0.05）.After 6 months’ treatment， the increase in fasting C-P and C-P 2 h in Group A was significantly elevated than those in Group B（ P<0.05）.The differences of FBG and BG 2 h had no statistical significance.Insulin dosage， time of BG to target and the frequency of hypoglycaemia were obviously lower
than those of Group B（ P<0.05）.Conclusion：The clinical effect of insulin pump therapy to incipient type 2 diabetes is almost equal to that of subcutaneous insulin infusion， whereas the former could shorten the time of blood glucose to target，reduce the dosage of insulin and the incidence of hypoglycemia with a quicker and smooth blood glucose control.The insulin pump therapy should be the first choice to the incipient type 2 diabetes patients.
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