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| The Effects of Ultra-filtration Technique on Pulmonary Function during Heart Valvular Replacement under Extracorporeal Circulation/ |
| The People’s Hospital of Qingyuan，Qingyuan 511518，China |
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Abstract Objective：To investigate the effect of using modified ultrafihration and balanced ultrafiltration on postoperative pulmonary function of patients with cardiac valvular replacement under extracorporeal circulation. Method：60 cases with heart valvular replacement were randomly divided into the control group（C），conventional ultrafiltration group（ D1）and balanced ultrafiltration with modified ultrafiltration group（D2）.The hematocrit（Hct），pulmonary function（OI、Cstat and P（A-a）O2），and the concentrations of tumor necrosis factor-α（TNF-α） Endothelin-1（EF-1） and interleukin-6（IL-6）in the three groups were respectively monitored at specific time points.Result：In group（ D1，D2） at T2，T3，T4 and T5 point OI was significantly higher than that in control group C（P<0.05）.In group D2 P（A-a）O2 at T3， T4 and T5 point was lower than in group（ D1，C）（P<0.05）.Cstat in group D2 was obviously higher than that of group（D1、C）.Hct of ultrafiltration in group（D1，D2） was significantly higher than that in the control group C（P<0.05）.The concentration of EF-1，TNF alpha and IL-6 in group D2 at T2，T3，T4，T5 point was lower significantly than the group（D1，C）（P<0.05）.Conclusion：Composite ultrafiltration can well improve the postoperative pulmonary function in patients with valvular replacement， reduced the concentration of EF-1 and inflammatory medium in the body.
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