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| The Study of Dexmedetomidine Combined with Pethidine in Reducing Shoulder Pain Caused by Laparoscopic underwent Combined Spinal-epidural Anesthesia |
| The Center Hospital of Jiaozhou， Jiaozhou 266300，China |
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Abstract Objective：To observe the effects of dexmedetomidine combined with pethidine alleviating shouler pain caused by laparoscopic underwent combined spinal-epidural anesthesia. Method：Sixty patients between 20 and 50 years，ASA class 1–2，scheduled for lower abdominal laparoscopy underwent combined spinal-epidural anesthesia were included in the study.Paintients were randomly assigned into three groups.Group A：patients were injected with
pethidine 0.8 mg/kg i.v.and infused with dexmedetomidine 1.0 μg/kg， and then 0.5 μg/（kg·h）after 10 minutes.Group B： patients were injected with pethidine 0.8mg/kg i.v.，normal saline was infused at the rate of dexmedetomidine in group A.Group C：patients were injected normal saline with the same dose insted of pethidine，and infused with dexmedetomidine 1.0 μg/kg， and then 0.5 μg/（kg·h）after 10 minutes.MAP，HR and shoulder pain were recorded during the operation.Result： MAP rose， HR increased after pneumoperitoneum in group B and，however kept steady group C.The incidence and severity of shoulder pain was lower in group A than in group B and in group C.Conclusion：Dexmedetomidine combined with pethidine could reduce the incidence and severity of shoulder pain caused by lower abdominal laparoscopy underwent combined spinal-epidural anesthesia.
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