Abstract Objective：To investigate the efficacy and safety of combining 1064nm Nd：YAG laser and collagen dressing for the treatment of moderate acne.Method：The 128 moderate acne cases were divided into laser treatment group of 44cases， laser and collagen dressing group of 44cases and control group of 40cases.The patients were treated for 4 sessions in a week interval and were treated with roxithromycin meanwhile.The laser was set to 35~40 J/cm2， with a 35 ms pulse duration， a repetition rate of 1.5 Hz and a spot size of 4 mm in diameter.In laser and collagen dressing group，after the laser treatment， each patient was given a collagen dressing for 30 min， and another collagen dressing 3 days later.Cases in control group were treated with roxithromycin.The efficacy was evaluated 4 weeks after the treatment.Result：The markedly effective rate in laser group and laser jion collagen dressing group 4 weeks after the treatment was 90.1% and 93.1% respectively， significantly higher than that of the control group， the differences were statistically significant （ P<0.05）.A follow-up of 2 months revealed the combination of 1064 nm Nd：YAG laser and collagen dressing improved the postinflammatory hyperpigmentation significantly，the differences were statistically significant（P<0.05）.Conclusion：The combination of 1064 nm Nd：YAG laser and collagen dressing could be a useful treatment alternative for patients with moderate acne.
