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| A Clinical Study of Clopidogrel Combined with Betahistine， Danshen Injection in the Treatment of Vertigoof VBI |
| Baokang TCM Hospital of Hubei，Baokang 441600，China |
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Abstract Objective： To evaluate the efficacy and safety of Clopidogrel Betahistine， Danshen injection inthe treatment of vertebral basilar insufficiency（ Vertebral-basilar artery insufficiency， VBI）. Method： Inclusion andexclusion criteria in strict accordance with VBI patients enrolled 120 cases， according to a list of random numbers into thetreatment group of 60 patients received Betahistine 10-30 mg， 5% dextrose injection or 0.9% sodium chloride injection，a after day 1， Danshen injection， intravenous infusion， a 10-20 mL with 5% glucose injection 100-500 mL diluted afteruse， day 1， and oral Clopidogrelbisulfate tablets， for the first time to give 600 mg， 150 mg/d. The control group receivedbetahistine joint compound Danshen injection. Two consecutive 7-21 d after treatment to assess the extent of the patient’svertigo， and using TCD to detect vertebral-basilar artery blood flow velocity and blood rheology， and follow 30 d， observedthe occurrence of recent TIA or cerebral infarction. Result： The treatment group was 0-2 h from patients and 0-6 heffective accounting effect from patients was 48.3%， 36.7%. The proportion of patients in the control group 0-2 h onsetpatients and 0-6 h onset was 28.3%， 58.3%. Treatment group was efficient， the total efficiency was 65.0% and 93.3%，respectively， in the control group significant efficiency， total efficiency of 41.7% and 75.0 %. There was significantdifference between the twogroups（ P<0.05）. After the triple therapy treatment group left vertebral artery， right vertebralartery， basilar artery blood flow velocity， blood viscosity， plasma viscosity， erythrocyte aggregation index improvedsignificantly better than the control group， a significant difference between the two groups（ P<0.05）. Long-term follow30 d， the treatment group 0 case of TIA or stroke occurred in the control group four cases occurred TIA， 1 case developedinto stroke incidence was 9.2%. There was significant difference between the two groups（ 字2=4.627， P=0.031）. Both
groups during the treatment of liver and kidney function did not change significantly after taking the drug. Treatment group1 patients had neutropenia，gastrointestinal adverse reactions occurred in 2 cases， nausea ， abdominal distension， etc.，shall not affect the continued drug use， the control group had no other adverse reactions. Conclusion： Clopidogrel andBetahistine， Danshen injection can significantly improve the vertebral-basilar artery insufficiency caused by vertigo，adverse reactions rarely occur during treatment.
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RUAN Lianguo,WEN Danning,HONG Ke,YU Ting,ZHANG Li,XIE Xuelei,CHEN Nanshan,HUANG Zhenghui,HUANG Chaolin. Randomized, Controlled and Open Clinical Study on the Efficacy and Safety of Honeysuckle Oral Liquid in the Treatment of Novel Coronavirus Infection (Damp-heat Accumulating Lung Syndrome)[J]. 中国医学创新, 2023, 20(6): 27-32. |
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