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| Effect of Comprehensive Rehabilitation on Neural Micro-angiogenesis in Rat with Sciatic Nerve Compression |
| Shenzhen No.2 People’s Hospital，Shenzhen 518000，China |
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Abstract Objective：To observe the the effect of comprehensive rehabilitation on neural micro-angiogenesis in rat with sciatic nerve compression.Method：According to the rat model of sciatic nerve compression designed by Mackinnon，forty male SD rats were chosen and randomly divided into 4 groups（n=10）：group A，group B，group C，and group D.After 2 weeks，compression were removed in all 4 groups，and no treatment was given in group A，rehabilitation training in group B，electroacupuncture in group C，electroacupuncture combined with rehabilitation training in group D.At 3 weeks after treatment，the sciatic nerve function index（ SFI），and the expression of CD34，VEGF in the compression sciatic nerve of rats were measured.Result：The SFI recovery rate of groups B，C，and D were significantly higher than that of group A（P<0.05），and that of group D was significantly higher than that of groups B and C（P<0.05）.The expression of CD34 and VEGF in the compression sciatic nerve of groups B，C，and D were significantly higher than that of group A（P<0.05），and that of group D was significantly higher than that of groups B and C（P<0.05）.Conclusion：Comprehensive rehabilitation can improve neural micro-angiogenesis in rat with sciatic nerve compression，thereby it can promote the nerve regeneration and functional recovery.
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