Abstract Objective：To investigate the protective effect of ginkgolide B on retinal ganglion cells after crush of intra orbital optic nerve in rats.Method：Thirty-six SD rats which were 46-day-old were randomly divided into noral control group（A group，12 rats），model control group（B group，12 rats）and Ginkgolide B group（C group，12 rats）.In each group，only the right eyes were used.No operation was carried out in normal control group，corresponding volume of NS or Ginkgolide B at 40 mg/kg was injected intraperitoneally into the rats from one week before crush until one week after crush in model control group or Ginkgolide
B group，one week and two weeks after operation，flash visual evoked potential were performed.Two weeks after operation，calculated the number of RGCs in each group.Result：one week after operation，the coefficients of LPl and APl were[（90±4）ms，（19±3）μV]，[（110±6）ms，（11±3）μV]and[（94±4）ms，（18±2）μV]respectively in noral control group，model control group and Ginkgolide B group，the differences were statistically significant among B group and A group or C group（P<0.05）.Two weeks after operation，the coefficients of LPl and APl were[（92±11）ms，（21±3）μV]，[（186±15）ms，（7±2）μV]and[（104±12）ms，（14±3）μV] respectively，the number of RGCs were（281±39），（112±20）and（228±35）respectively，the differences were statistically significant in 3 groups（P<0.05）.Conclusion：Ginkgolide B can partly inhibit the apoptosis of RGCs and promote the survival of RGCs after crush of intra orbital optic nerve.
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