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| The Changes of Cerebral White Matter MR Diffusion Tensor Imaging of Brain on Patients of Mild Cognitive Impairment and Its Relationship with Cognitive Dysfunction |
| The People’s Hospital of Puning City， Puning 515300，China |
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Abstract Objective：To analyze the changes of cerebral white matter MR diffusion tensor imaging of brain on patients of mild cognitive impairment and the correlation with cognitive dysfunction.Method：120 patients with mild cognitive impairment admitted in our hospital from July 2012 to July 2014 were selected as the study object， in accordance with no deep white matter ischemia were divided into ischemia group（ n=78） and non myocardial ischemia group（ n=42），and 30 cases of healthy normal people were selected as control group， the three groups object were respectively given conventional magnetic resonance diffusion tensor imaging and detection， and using MoCA（ Montreal cognitive） scale and MMSE（ mental state） rating scale evaluated mental status of the object and cognitive function， and cognition of white matter changes and function correlation between barrier in brain of three groups were observed.Result：The function of ischemic group cognitive outcome score of（ 20.29±2.00）， was significant lower than the ischemia group（ 22.11±2.26），the comparison between the two groups had obvious difference（ P<0.05）； compared with non ischemia group， ischemia group frontal ADC were increased， FA value decreased significantly（ t=4.228， 3.250， P<0.05）， parietal ADC value increased， FA value decreased obviously（ t=2.701， 7.532， P<0.05）； compared with the control group， non ischemia group frontal ADC increased， FA decreased（ t=7.791， 2.874， P<0.05）， parahippocampal gyrus ADC upgraded ， FA decreased（ t=4.414， 5.163， P < 0.05）.Conclusion：In clinical diagnosis of patients with MCI， using MR diffusion tensor imaging detection can quantifiable analysis of cerebral white matter lesions level of patients， determine the possibility of conversion to Alzheimer’s disease， and provide guidance for early treatment of patients， is worthy of promotion.
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