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Abstract Objective：To investigate the proportion of Adenosine deaminase 2（ADA2） in total ADA activity of the tuberculosis pleural effusion and its cellular source in pleural tissue.Method：The total ADA and ADA2 activity from thirty-two tuberculosis patients’ effusions were measured.The cellular source of ADA2 were examined by immunohistochemistry method using CECR1 antibody.Result：The ADA2 contributed 74.8% to the total ADA.The immunohistochemistry of ADA2 in the pleural tissues of tuberculous pleural effusion showed that langhans cells，epithelioid cells and macrophages were stained deeply.Their cytoplasm and membrane were deposited by yellow granules.Conclusion：ADA2 is primarily responsible for total ADA activity in tuberculosis pleural effusion and it is secreted by macrophages，epithelioid cells and langhans cells.
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