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| Clinical Value of Blood，Urine Cystatin C in Different Periods of the Hemorrhagic Fever with Renal Syndrome Acute Kidney Injury |
| Boluo County People’s Hospital of Huizhou，Boluo 516100，China |
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Abstract Objective：To investigate the clinical value of serum and urinary cystatin C（ CYS） in the different period of hemorrhagic fever with renal syndrome（ HERS） in patients with acute kidney injury（ AKI）.Method：From March 2010 to October 2012 in our hospital，36 cases of renal syndrome hemorrhagic fever were selected as observation group in this study，36 cases of specimens were also selected as the basis to clinical stage and were divided into the heating period/hypotension shock stage，oliguria stage，transition stage and polyuria period/recovery period；at the same time were selected for health examination in our hospital in 35 normal subjects as control group in this study.Serum creatinine in two groups of subjects was determined by enzymatic method，using enzyme-linked immunosorbent assay for two groups of subjects，blood urine cystatin C were determined，and the structure determination of two groups of patients were analyzed.Result：In period of fever period/ hypotension，shock stage，less urine period，transition period and diuresis/recovery phase，serum cystatin C，urine cystatin C and serum creatinine level had significant difference between the observation group and the control group（P<0.05），and there were statistically significant differences in the serum，serum creatinine and urinary cystatin C between the purification group and no purification group（P<0.05）.Conclusion：Markers in serum and urine cystatin C as hemorrhagic fever with renal syndrome of
acute kidney injury，can effectively respond to the severity of acute kidney injury in patients，renal syndrome of urinary cystatin C and renal tubular injury more consistent hemorrhagic fever of acute kidney injury，clinical value is significant，can be widely used in large range in the clinical.
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