中国医学创新  2015, Vol. 12 Issue (18): 127-128    DOI: 10.3969/j.issn.1674-4985.2015.18.048
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The Effect of Surgical Castration on Lipid Metabolism in Patients with Prostate Cancer
The People’s Hospital of Songgang,Shenzhen 518105,China
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Abstract  Objective:To analyze the effect of surgical castration on lipid metabolism in patients with prostate cancer.Method:45 patients with advanced prostate cancer had undergone the bilateral orchiectomy.The serum levels of T,FT,TG,TC,HDL-C,LDL-C,APO-A1,APO-B were determined before and after castration.Result:T and FT after castration were significantly lower than that before castration,and showed a gradual decrease from 1 month to 1 year,the differences were statistically significant(P<0.05);after castration,TG increased significantly 3 months after castration,TC and HDL-C increased significantly after castration,LDL-C decreased significantly after castration,the differences were statistically significant(P<0.05).APO-A1 and APO-B were not changed,the difference was no statistically significant(P<0.05).Conclusion:After surgical castration,the androgen levels decrease,and the lipid metabolism becomes abnormal.
Key wordsSurgical castration      Prostate cancer      Lipoprotein     
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