Abstract Objective：To analyze the effect of surgical castration on lipid metabolism in patients with prostate cancer.Method：45 patients with advanced prostate cancer had undergone the bilateral orchiectomy.The serum levels of T，FT，TG，TC，HDL-C，LDL-C，APO-A1，APO-B were determined before and after castration.Result：T and FT after castration were significantly lower than that before castration，and showed a gradual decrease from 1 month to 1 year，the differences were statistically significant（P<0.05）；after castration，TG increased significantly 3 months after castration，TC and HDL-C increased significantly after castration，LDL-C decreased significantly after castration，the differences were statistically significant（P<0.05）.APO-A1 and APO-B were not changed，the difference was no statistically significant（P<0.05）.Conclusion：After surgical castration，the androgen levels decrease，and the lipid metabolism becomes abnormal.
