Abstract Objective：To observe the effect and safety of non-weight exercise prescription for patients with diabetic foot ulcer（DFU）.Method：Sixty-two patients with DFU were divided into exercise group and control group at random，We observed the changes of local skin temperature， ankle brachial index（ ABI），transcutaneous oxygen
pressure（TcPO2） and the effect evaluation of DFU before and after treatment；the ulcer healing rate in the two groups were compared，and the adverse events of the treatment were recorded.Result：The total efficacy rate in the exercise group was significant better than that in the control group after treatment（P<0.05）.The ABI，TcPO2 in the two groups increased.Besides， there is aincrease of local skin temperature and a decrease of BMI in exercise groups（P<0.05）. The differences of above index before and after treatment in exercise groups are more significant than that in control group（P<0.05 or P<0.01）.Conclusion：The non-weight exercise prescription in the study can improve the foot perfusion and promote ulcer healing.It has the advantage of high safety.
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