Abstract Objective：To clarify the effects of Telmisartan combined with Spironolactone on early recurrence after catheter ablation for paroxysmal atrial fibrillation in patients.Method：96 patients with PAF treated by catheter ablation were randomly divided into control group and observational group，48 cases in each group，the control group was treated with Warfarin and Amiodarone，the observational group was treated with Telmisartan and Spironolactone.Result：The rate of PAF early recurrence in observational group was 6.25%，which was significantly lower than 22.92% of the control group，the difference was statistically significant（ P<0.05）.After surgery 1 month，HsCRP in observational group was higher than the control group；after surgery 3 month，NT-proBNP in observational group was lower than the control group，the differences were statistically significant （P<0.05）.Conclusion：Telmisartan combined with Spironolactone reduce early recurrence after catheter ablation of PAF.
