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Abstract Objective：To investigate influence of pre-injection Butorphanol on myoclonus caused by Etomidateduring induction of general anesthesia.Method：To be under general anesthesia for elective surgery were 180 cases，ASA Ⅰ or Ⅱ， male 85 cases， female 95 cases， aged 20 to 65 years old， weighing 42-59 kg， were randomly divided intobutorphanol group（ group B）， Sufentanil group（ S group） and control group（ N group）， 60 cases in each group. GroupB received butorphanol 20 μg/kg（ total not more than 2 mg）； S group received sufentanil 0.2 μg/kg， N group given thesame volume of saline， 1 min threegroups of patients after intravenous injection of etomidate acetate 0.3 mg/kg， injectiontime 30 s and continued to observe for 2 min， spasm conditions was observed and the severity was assessed.Result：Ofthe three groups of patients during induction BP， HR difference was not statistically significant， all patients SpO2> 97%；compared with the N group， group B， S myoclonic patients significantly reduced the number of cases 1，2，3，muscleArray twin significantly lower incidence（P<0.05）.Conclusion：Preinjection 20 μg/kg butorphanol can effectivelyreduce lead time etomidate induced myoclonus occur.
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