Abstract Objective： To explore the curative effect observe of gene modified bone marrow mesenchymal stem cells transplantation on acute myocardial infarction in rats.Method： 20 SD rats of 15 day old were selected and divided into two groups，the observation ervation group（ vascular endothelial growth factor group） and control group（ DMEM group）， 10 rats in each group， thepreparation of acute myocardial infarction model， the observation group rats underwent gene modified bone marrow mesenchymal stem cells transplantation，the control group rats were injected with serum free DMEM， after one month transplantation，the cardiac function of two groups were observed. Result： The observation group and the control group LVEF rats were respectively
（73.45±9.17）% and（ 43.26±6.33）%， the observation group was significantly higher than that in the control group， the difference was statistically significant（P<0.05）；two groups of rats were found with microscope in the formation of left ventricular scar tissue，with angiogenesis and the emergence of remodeling left ventricular， compared with the control group，the observation group rats heart changed significantly； the observation group and the control group of rats with vascular density of rats were respectively（ 45.69±4.28） and（ 17.41±3.67）， the observation group was significantly higher than that in the control group， the difference was statistically significant（P<0.05）. Conclusion： Vascular endothelial growth factor gene modified bone marrow mesenchymal stem cells transplantation has good therapeutic effect on acute myocardial ischemia in rats.
