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Abstract Objective：To detect normal fetal restricted normal term placenta and fetal placental activin receptor expression，analyze activin receptor expression and fetal growth retardation.Method：16 cases of fetal growth restriction at term placenta were selected as the observation group and 15 cases of normal term placenta were selected as a control group，placental tissue by HE staining analysis，site of placental tissue expression of activin receptor by immunohistochemistry method analyzed and semi-quantitative analysis，activin receptor mRNA expression level in the placenta by PCR analyzed.Result：The activin receptor ⅠA，ⅠB expression was not significantly different of the two groups（P>0.05），the observation group type ⅡA and ⅡB in（ ++），（+++） percentage were higher than the control group（ P<0.05）；the observation group type ⅡA and ⅡB in（ -） the percentage of significantly lower than control group（ P<0.05）.Placental tissue of patients in the observation group activin receptor ⅠA，ⅠB and gene expression in the control group no significant difference（P>0.05），placenta observation group ⅡA，ⅡB expression was significantly higher（P<0.05）.Conclusion：Fetal growth restriction placental activin levels were significantly higher than normal placenta，activin disorder can lead to fetal growth restriction.
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