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Abstract Objective：To explore the changes and clinical significance of serum transferrin and C reactive protein in neonatal jaundice.Method：100 cases of neonatal jaundice were selected from March 2013 to March 2014 in our hospital and were grouped according to the causes and total bilirubin levels of neonatal jaundice.50 full-term and no jaundice newborns were selected as control group during the same time period.The serum TRF and CRP levels of children in different group were completed.Result：The serum TRF and CRP levels of infection factors group，perinatal factors group and other factors group compared with the control group，the differences were statistically significant（P<0.05）.But there was no significant difference in the serum TRF levels among the three groups（P>0.05）. C reactive protein level of infection factors group was significantly higher than perinatal factors group and other factors group，the differences were statistically significant（P<0.05）.The serum TRF and CRP levels of mild jaundice group，moderate jaundice group and severe jaundice group compared with the control group，the differences were statistically significant（P<0.05）.But there was no significant difference in the serum TRF level among the three groups（P>0.05）.C reactive protein level of severe jaundice group was significantly higher than mild，moderate jaundice group，the differences were statistically significant（P<0.05）.Conclusion：Serum TRF and CRP levels have certain clinical value in differentiating etiology and disease of neonatal jaundice.
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