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Abstract Objective：To investigate the effect of cardiovascular events recurrence risk of urokinase pre-hospital thrombolytic therapy for acute myocardial infarction.Method：89 cases of acute myocardial infarction from Cardiology department were selected，pre-hospital thrombolysis therapy were as observation group，post-hospital thrombolytic treatment were as control group，NT-proBNP，hs-CRP were detected by ELISA，the difference of coronary recanalization rate，NT-proBNP and hs-CRP levels between groups were compared.Result：The coronary artery recanalization rate of observation group was significantly higher than control group（P<0.05），before treatment，NT-proBNP and hs-CRP level had not statistically significant difference between two groups（P>0.05），after treatment， all above indexes showed elevated tendency， which observation group were significantly lower than control group，with significant differences（P<0.05），cardiovascular events（angina recurrence，recurrent AMI and heart failure occurring）were significantly reduced，the difference between two groups was significant（P<0.05）.Conclusion：Urokinase pre-hospital thrombolytic therapy helps improving coronary reperfusion and reducing cardiovascular events recurrent risk for acute myocardial infarction，it may be related to significantly inhibit NT-proBNP，hs-CRP level.
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