Objective: To explore the effect of blood letting therapy combined with Hydroxycarbamide and Aspirin in the treatment of polycythemia vera. Method: A total of 60 patients with polycythemia vera admitted to the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology from January 2021 to January 2022 were selected and randomly divided into observation group and control group according to coin toss method, with 30 cases in each group. Patients in the the control group were treated with Hydroxycarbamide combined with blood letting therapy, and patients in the the observation group were treated with low-dose Aspirin based on the control group. The clinical efficacy, coagulation function, hematological indexes, adverse reactions, myeloproliferative neoplasm symptom assessment form total symptom score (MPN-SAF-TSS) and incidence of thrombus were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the incidence of thrombus was lower than that of the control group (P<0.05). Before treatment, there were no significant differences in coagulation function indexes between the two groups (P>0.05); after treatment, the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) in both groups were longer than those before treatment, and the APTT, PT and TT in the observation group were longer than those in the control group, and the fibrinogen (FIB) levels of both groups were decreased, and the FIB level of observation group was significantly lower than that of control group (P<0.05). Before treatment, there were no significant differences in red blood cell (RBC), hemoglobin (Hb), platelet (PLT) and white blood cell (WBC) levels between the two groups (P>0.05); after treatment, RBC, Hb, PLT and WBC levels in both groups were decreased, and RBC, Hb, PLT and WBC levels in observation group were significantly lower than those in control group (P<0.05). After treatment, MPN-SAF-TSS score of observation group was lower than that of control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Blood letting therapy combined with Hydroxycarbamide and Aspirin in the treatment of polycythemia vera can not only improve the coagulation function and hematological indexes of patients, but also improve the therapeutic effect, reduce the incidence of thrombus in patients, and do not increase adverse reactions.

2023 Vol. 20　(26):　1-5 [Abstract]（ 242 ） HTML (1 KB)  PDF  (931 KB)  ( 152 )

Objective: To investigate the application effect of balanced ultrafiltration technique in the treatment of pediatric congenital heart disease by direct intracardiac surgery under extracorporeal circulation. Method: A total of 86 children with congenital heart disease treated in Tai’an Maternity and Child Health Hospital from January 2021 to December 2022 were selected and divided into control group (n=43) and observation group (n=43) by random number table method. The control group received conventional ultrafiltration, and the observation group received balanced ultrafiltration. Interleukin-6 (IL-6), interleukin-10 (IL-10) and hypersensitive C reactive protein (hs-CRP) were compared between the two groups at different times [before cardiopulmonary bypass (T0), immediately after ultrafiltration (T1), 24 h after surgery (T2), 48 h after surgery (T3), 72 h after surgery (T4)]; the pulmonary function [(P(A-a)O2, pulmonary artery pressure (PAP)] of the two groups were compared before, immediately after surgery, 24 h after surgery and 48 h after surgery; the postoperative recovery (the time of using vasoactive drugs, the time of using ventilator, and the length of ICU stay) of the two groups of children were compared surgery. Result: T0, IL-6, IL-10, hs-CRP levels between the two groups were not statistically significant (P>0.05); the levels of IL-6 at T1, T2, T3 and T4 in both groups were higher than those at T0, and the levels of IL-6 at T2, T3 and T4 in observation group were lower than those in control group, the differences were statistically significant (P<0.05); the IL-10 levels at T1, T2, T3 and T4 in two groups were higher than those at T0, and the IL-10 levels at T1, T2, T3 and T4 in observation group were lower than those in control group, the differences were statistically significant (P<0.05); the hs-CRP levels at T1, T2, T3 and T4 were higher than those at T0, and the hs-CRP levels at T2, T3 and T4 in observation group were lower than those in control group, the differences were statistically significant (P<0.05). Before operation, there were no significant differences in P(A-a)O2 and PAP between the two groups (P>0.05); P(A-a)O2 were higher than T0 immediately after surgery, 24 h after surgery and 48 h after surgery in both groups, but P(A-a)O2 in observation group were lower than those in control group, the differences were statistically significant (P<0.05); immediately after surgery, 24 h after surgery and 48 h after surgery, PAP in both groups were lower than those at T0, and PAP in observation group were lower than those of the control group, the differences were statistically significant (P<0.05). The time of vasoactive drug use, ventilator use and ICU stay in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). Conclusion: In children with congenital heart disease, there will be inflammation in the body during open heart surgery, balanced ultrafiltration technology can reduce the inflammation, reduce the injury, protect the lung function and promote the postoperative recovery of the children.

2023 Vol. 20　(26):　10-14 [Abstract]（ 219 ） HTML (1 KB)  PDF  (1018 KB)  ( 294 )

Objective: To investigate the effect of Recombinant Humanized Anti IL-6R Monoclonal Antibody on the clinical efficacy and bone metabolism in rheumatoid arthritis (RA). Method: A total of 60 patients diagnosed with RA in Pingxiang People's Hospital from August 2019 to March 2022 were selected and divided into treatment group and control group according to random number table method, with 30 patients in each group. The treatment group was treated with Recombinant Humanized Anti IL-6R Monoclonal Antibody + Methotrexate + stable dose Prednisone, while the control group was treated with Methotrexate + stable dose Prednisone. The C reactive protein, rheumatoid factor, erythrocyte sediment, osteocalcin (OC) and bone mineral density of the two groups were detected before treatment and 3 and 6 months after treatment, visual analogue scale (VAS) score, Sharp score and safety of the two groups were evaluated. Result: After 3 and 6 months of treatment, the C reactive protein, rheumatoid factor, erythrocyte sedimentation rate and VAS scores in two groups were significantly lower than those before treatment (P<0.05), and the above indexes in the treatment group were significantly lower than those in the control group (P<0.05). The OC of 3 and 6 months after treatment in both groups were higher than those before treatment (P<0.05), and the OC of 3 and 6 months after treatment in the treatment group were higher than those of control group (P<0.05). There were no significant differences in femoral neck bone mineral density before and after treatment between the two groups and within two groups (P>0.05). Sharp scores of 3 and 6 months after treatment in the two groups were lower than those before treatment (P<0.05), and Sharp scores of 3 and 6 months after treatment in the treatment group were lower than those in the control group (P<0.05). The incidence of adverse events in the treatment group was higher than that in the control group, but there was no significant difference between the two groups (P>0.05). Conclusion: Recombinant Humanized Anti IL-6R Monoclonal Antibody can effectively reduce the levels of C reactive protein, rheumatoid factor and erythrocyte sink in RA patients, relieve their pain, increase OC, reduce Sharp score, and do not increase the occurrence of adverse events, with high safety.

2023 Vol. 20　(26):　19-23 [Abstract]（ 234 ） HTML (1 KB)  PDF  (986 KB)  ( 97 )

Objective: To investigate the effect of Aripiprazole combined with Haloperidol in the treatment of tics-coprolalia syndrome children, explore the pharmacological mechanism and observe the effect of combined treatment on antistreptolysin O (ASO) levels. Method: A total of 122 children with tics-coprolalia syndrome admitted to Fujian Children's Hospital from May 2021 to May 2022 were randomly divided into the control group and the observation group, with 61 cases each group. The control group was treated with Haloperidol, and the observation group was treated with Aripiprazole combined with Haloperidol. After 12 weeks of follow-up, clinical efficacy, neurological function indexes, ASO levels and adverse drug reactions were compared between the two groups. Result: After treatment, the Yale global tic severity scale (YGTSS) scores of motor tic and vocal tic in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05); the total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05), the levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and ASO in the observation group were lower than those in the control group, the level of γ-aminobutyric acid (GABA) was higher than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Aripiprazole combined with Haloperidol can effectively improve motor tic and vocal tic symptoms in children with tics-coprolalia syndrome, and reduce the level of ASO, it is safety.

2023 Vol. 20　(26):　28-32 [Abstract]（ 252 ） HTML (1 KB)  PDF  (1002 KB)  ( 86 )

Objective: To investigate the effect of Dexmedetomidine combined with subanesthetic dose Esketamine Hydrochloride on analgesia and sedative effects in elderly patients undergoing percutaneous vertebroplasty. Method: A total of 102 elderly patients underwent percutaneous vertebroplasty admitted to Pingxiang NO.2 People's Hospital from February 2020 to February 2022 were selected as the study objects, and were divided into conventional group (n=51, Sufentanil + Dexmedetomidine) and observation group (n=51, Dexmedetomidine + subanesthetic dose Esketamine Hydrochloride) according to random number table method. Hemodynamics indexes [heart rate, mean arterial pressure (MAP), central venous pressure (CVP)], postoperative pain situation, incidence of restlessness and adverse reactions were compared between the two groups. Result: Induction of anesthesia (T1) and 2 min after operation (T2), MAP, heart rate and CVP of observation group were lower than those of conventional group, the differences were statistically significant (P<0.05). The restlessness degree of the observation group was lower than that of the conventional group, the difference was statistically significant (P<0.05). The Prince-Henry scores of the observation group at 9, 18 and 36 h after operation were lower than those of the conventional group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dexmedetomidine combined with subanesthetic dose Esketamine Hydrochloride in elderly patients undergoing percutaneous vertebroplasty can stabilize intraoperative hemodynamics, which is conducive to reducing the risk of restlessness, alleviating postoperative pain, and has good safety.

2023 Vol. 20　(26):　37-40 [Abstract]（ 184 ） HTML (1 KB)  PDF  (1026 KB)  ( 298 )

Objective: To investigate the application effect of mixed filling of bone cavity with concentrated growth factor (CGF) and allogeneic bone particles combined with biofilm covering in bone augmentation for odontogenic cysts. Method: A total of 60 patients with odontogenic cysts who were admitted to the Stomatology Department of Shangrao People's Hospital from July 2021 to December 2022, and needed bone augmentation during operation were selected and divided into observation group (n=30) and control group (n=30) according to random number table method. The observation group was treated with biofilm covering after mixed filling of bone cavity with CGF and allogeneic bone particles, while the control group was treated with mixed filling of bone cavity with CGF and allogeneic bone particles. Clinical efficacy, postoperative infection, postoperative recovery of teeth with loss of function, and Vancouver scar scale (VSS) scores were compared between the two groups. Result: The total treatment effective rate in the observation group (90.00%) was higher than that in the control group (66.67%) (P<0.05). Three months after operation, there was 1 case of mild infection and 3 cases of severe infection in the observation group, 3 cases of mild infection and 10 cases of severe infection in the control group, the difference in infection between the two groups was statistically significant (P<0.05). The recovery of affected teeth in the observation group was better than that in the control group (P<0.05). The VSS scores of the observation group were lower than those of the control group at 1 week, 2 weeks and 4 weeks after operation (P<0.05). Conclusion: Mixed filling of bone cavity with CGF and allogeneic bone particles combined with biofilm covering can enhance the therapeutic effect of bone augmentation on odontogenic cyst, promote the recovery of affected teeth, reduce the incidence of postoperative infection, and inhibit scar formation after operation.

2023 Vol. 20　(26):　45-48 [Abstract]（ 216 ） HTML (1 KB)  PDF  (1022 KB)  ( 212 )

Objective: To explore the clinical effect of using Ambroxol Hydrochloride combined with Azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children. Method: A total of 120 children with mycoplasma pneumoniae pneumonia treated in the Department of Pediatrics of Xinyu Hospital of Traditional Chinese Medicine from August 2019 to August 2022 were selected. They were equally divided into the control group (60 cases) and the observation group (60 cases) by the random number table method, Azithromycin treatment and Azithromycin combined with Ambroxol Hydrochloride treatment were administered sparately. Lung function, recovery of clinical indicators, inflammatory reaction, clinical efficacy and incidence of adverse effects were compared between the two groups. Result: Before treatment, there were no significant differences in lung function indexes between the two groups (P>0.05); after treatment, the levels of lung function indexes in the observation group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). Recovery of clinical indicators of children in the observation group were significantly shorter than those in the control group (P<0.05). There were no significant differences in the levels of inflammatory factors between the two groups before treatment (P>0.05); after treatment, the levels of interleukin-6 (IL-6), C reactive protein (CRP), and serum amyloid A (SAA) in the observation group were significantly lower than those in the control group, the differences were statistically significant (P<0.05). The total clinical response rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The treatment of Ambroxol Hydrochloride combined with Azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia can significantly improve lung function, recovery of clinical indicators, and reduce inflammatory reactions.

2023 Vol. 20　(26):　53-57 [Abstract]（ 190 ） HTML (1 KB)  PDF  (1150 KB)  ( 409 )

Objective: To explore the effect of Huoxue Tongluo Heji combined with conventional western medicine on cerebral infarction and its influence on hemodynamics. Method: A total of 86 patients with cerebral infarction admitted to Xuzhou Hospital of TCM from January 2021 to January 2022 were selected and divided into observation group and control group using random number table method, with 43 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Huoxue Tongluo Heji on the basis of the control group. The total effective rate, nerve function related score, hemodynamic index and serum related index of the two groups were compared. Result: The total effective rate of treatment in the observation group (97.67%) was higher than that in the control group (83.72%), the difference was statistically significant (P<0.05). Before treatment, there were no statistically significant differences in the NIHSS, MoCA and FMA scores between the two groups (P>0.05); 6 months after treatment, the NIHSS scores of both groups decreased, and the observation group was lower than that of the control group, MoCA scores and FMA scores were both increased, and the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, hematocrit, fibrinogen and sedimentation rate between the two groups (P>0.05); 6 months after treatment, the indexes of both groups were decreased, and the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in the levels of C reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and neuron-specific enolase (NSE) between the two groups (P>0.05); 6 months after treatment, the levels of CRP, IL-6, IL-8, MMP-9

2023 Vol. 20　(26):　63-67 [Abstract]（ 235 ） HTML (1 KB)  PDF  (1117 KB)  ( 78 )

Objective: To explore the effect of Bacterial Lysates Capsules combined with modified Dingchuan Decoction in the treatment of children with repeated gasping, in order to provide an effective treatment plan for children with this disease. Method: A total of 120 children with repeated gasping received from Maternity and Child Care Center of Xinyu from January 2020 to January 2022 were divided into a combination group and a routine group according to computer random number table method, with 60 cases in each group. The routine group received routine treatment, and the combination group was treated with Bacterial Lysates Capsules combined with modified Dingchuan Decoction on the basis of the routine group. The therapeutic effect, humoral immunity indexes, serum inflammatory factor indexes and blood routine indexes were compared between the two groups. Result: The number of gasping attacks in the combination group was less than that in the routine group, and the duration of each attack was shorter than that in the routine group (P<0.05). After treatment, the immunoglobulin (Ig) A and IgG levels in combination group were higher than those in routine group (P<0.05). After treatment, the levels of serum inflammatory factors in combination group were better than those in routine group (P<0.05). After treatment, compared with the levels of blood routine indexes, those in the combination group were better than those in the routine group (P<0.05). Conclusion: Bacterial Lysates Capsules combined with modified Dingchuan Decoction in the treatment of children with repeated gasping has a remarkable effect, and can reduce inflammatory reaction.

2023 Vol. 20　(26):　72-75 [Abstract]（ 177 ） HTML (1 KB)  PDF  (1065 KB)  ( 333 )

Objective: To analyze the effect of acupuncture combined with massage on the pain and joint function of patients with shoulder arthralgia after stroke. Method: A total of 108 patients with shoulder joint pain after stroke admitted to Tai’an Rongjun Hospital from March 2020 to October 2022 were included in the study, and were divided into the observation group (54 cases) and the control group (54 cases) according to the method of computer random number table. The control group was treated with massage, and the observation group was treated with acupuncture on the basis of the control group. The pain degree and joint function of the two groups were compared. Result: After treatment, the total effective rate of the observation group was higher than that of the control group (P<0.05); after treatment, the symptom scores of the two groups were lower than those before treatment, and the symptom scores of the observation group were lower than those of the control group (P<0.05); after treatment, the visual analogue scale (VAS) scores and disability of the arm, shoulder and hand (DASH) scores of the two groups were lower than those before treatment, and the scores of the observation group were lower than those of the control group (P<0.05); after treatment, the FMA upper limb scores, MBI scores and ADL scale scores of the two groups were higher than those before treatment, and the above scores in the observation group were higher than those in the control group (P<0.05). Conclusion: The application of acupuncture and massage in the treatment of shoulder arthralgia after stroke can relieve shoulder joint pain, promote the recovery of upper limbs function and improve self-care ability.

2023 Vol. 20　(26):　80-84 [Abstract]（ 247 ） HTML (1 KB)  PDF  (1179 KB)  ( 129 )

Objective: To study the effect of diversification nursing mode on sense of coherence-13 (SOC-13) score, Chinese version of acceptance of illness scale (AIS-CHI) score and pulmonary function in elderly patients with chronic persistent of asthma. Method: A total of 80 elderly patients with chronic persistent of asthma admitted to the First Affiliated Hospital of Xiamen University from December 2021 to December 2022 were selected as the study objects. According to the random number table method, the participants in the study were divided into routine group and management group, with 40 cases in each group. The routine group adopted the routine nursing mode, and the management group adopted the diversification nursing mode based on the routine group. Nursing effect, SOC-13 score, AIS-CHI score and pulmonary function were compared between the two groups. Result: The nursing effect of management group was better than that of conventional group (P<0.05). At discharge and 2 months after nursing, the SOC-13 scores in the management group were higher than those in the conventional group, after 5 days of nursing and at discharge, AIS-CHI scores in the management group were higher than those in the conventional group (P<0.05). After nursing, the pulmonary function indexes in management group were higher than those in conventional group (P<0.05). Conclusion: Applying diversification nursing mode to elderly patients with chronic persistent of asthma can significantly improve their sense of coherence and acceptance of illness, and improve their pulmonary function.

2023 Vol. 20　(26):　89-93 [Abstract]（ 234 ） HTML (1 KB)  PDF  (1247 KB)  ( 113 )

Objective: To investigate the application of kangaroo mother care in premature infants with automatic auditory brainstem response (AABR). Method: A total of 60 premature infants admitted to the First People's Hospital of Fuzhou from January to September 2021 were selected. They were randomly divided into the kangaroo group (30 cases) and the routine group (30 cases). The routine group was treated with routine nursing. The kangaroo group was treated with kangaroo mother care on the basis of the routine group. The examination preparation time, environmental noise level value, detection time, completion time of AABR recording, screening pass rate and test status in the two groups were compared. Result: The time of preparation, detection, and AABR recording in the kangaroo group were significantly shorter than those in the routine group (P<0.05). There was no significant difference in the level of environmental noise between the two groups (P>0.05). The compliance and pass rate of primary screeing in the kangaroo group were significantly higher than those of the routine group, and the test status was significantly better than that of the routine group (P<0.05). Conclusion: Kangaroo mother care can help premature infants perform AABR detection efficiently and smoothly, reduce the impact of sound and light stimulation, shorten hearing screening time, and improve screening efficiency.

2023 Vol. 20　(26):　98-101 [Abstract]（ 209 ） HTML (1 KB)  PDF  (1164 KB)  ( 154 )

Objective: To observe the effect of Fu's subcutaneous needling combined with traditional Chinese medicine hot package nursing on lumbago of Qi stagnation and blood stasis type. Method: A total of 82 patients with lumbago of Qi stagnation and blood stasis type admitted to Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from April 2020 to June 2022 were selected and divided into reference group and study group according to random number table method, with 41 cases in each group. The reference group received routine nursing + Fu's subcutaneous needling nursing, and the study group received routine nursing + Fu's subcutaneous needling nursing + traditional Chinese medicine hot package nursing. Total effective rate of nursing, pain degree [visual analogue scale (VAS)], lumbar function [Oswestry disability index (ODI)] and range of motion of lumbar were compared between the two groups. Result: The total effective rate of the study group was higher than that of the reference group, the difference was statistically significant (P<0.05). After 20 days of nursing, VAS score and ODI score in the study group were lower than those in the reference group, and lumbar flexion and dorsal in the study group were higher than those in the reference group, the differences were statistically significant (P<0.05). Conclusion: Patients with lumbago of Qi stagnation and blood stasis type are treated with Fu's subcutaneous needling combined with traditional Chinese medicine hot package nursing have better nursing effect, which can reduce pain degree, improve lumbar function and increase the range of motion of lumbar.

2023 Vol. 20　(26):　106-109 [Abstract]（ 193 ） HTML (1 KB)  PDF  (1136 KB)  ( 129 )

Objective: To investigate the effects of oral exercise intervention combined with early micro-feeding on gastrointestinal complications and neurobehavioral development in premature infants. Method: A total of 114 premature infants admitted to the Neonatology Department of Yingtan City People's Hospital from October 2020 to July 2022 were selected and randomly divided into observation group (57 cases) and control group (57 cases). The control group was given routine nursing care + early micro-feeding, the observation group was given oral exercise intervention on the basis of the control group. The gastrointestinal complications, prognosis and neurobehavioral development of two groups were compared. Result: The incidence of gastrointestinal complications such as diarrhea, vomiting, abdominal distension and gastric retention of the observation group were lower than those of the control group (P<0.05). The time of weight correction, nasogastric tube retention and complete oral feeding of the observation group were shorter than those of the control group, the milk intake of the observation group was higher than that of the control group on the 7th day after birth (P<0.05). After intervention, the total scores of neurobehavior and scores of all dimensions in the observation group were higher than those in the control group (P<0.05). Conclusion: Oral exercise intervention combined with early micro-feeding can effectively prevent gastrointestinal complications in premature infants, and is beneficial to the recovery of gastrointestinal function and neurobehavioral development, and improve the prognosis of premature infants.

2023 Vol. 20　(26):　114-118 [Abstract]（ 201 ） HTML (1 KB)  PDF  (1238 KB)  ( 106 )

Objective: To evaluate the effect of remote ischemic preconditioning (RIPC) on cognitive ability in patients with subcortical ischemic vascular dementia (SIVD). Method: A total of 74 patients with SIVD diagnosed and treated in Jiamusi Central Hospital from January 2019 to January 2021 were selected and divided into the treatment group (36 cases) and the control group (38 cases) according to random number table method. The treatment group was treated with RIPC treatment and the control group was treated with placebo for 3 months. The cognitive ability scores, serum inflammatory factors and MRI parameters of the two groups were compared before and after treatment. Result: There were no significant differences in cognitive ability scores, serum inflammatory factors and imaging parameters between the two groups before treatment (P>0.05). After treatment, Hopkins verbal learning test-revised (HVLT-R), controlled oral word association test (COWAT), trail making test A and B (TMT-A, TMT-B) and judgment of line orientation (JLO) scores in the treatment group were better than those before treatment (P<0.05); all the inflammatory factors in the treatment group were lower than those before treatment and those in the control group (P<0.05), in the control group, only HVLT-R and TMT-B scores were significantly better than those before treatment (P<0.05). Before and after treatment, there were no significant differences in MRI parameters between the two groups (P>0.05). All patients successfully completed the treatment without obvious adverse reactions. Conclusion: RIPC can improve the cognitive function of SIVD patients to a certain extent without obvious adverse reactions.

2023 Vol. 20　(26):　122-126 [Abstract]（ 210 ） HTML (1 KB)  PDF  (1389 KB)  ( 73 )

Objective: To investigate the effect of low-dose Aspirin therapy on improving maternal and infant outcomes in patients with high-risk of pre-eclampsia (PE). Method: A total of 86 patients with high-risk of PE risk predicted in Maternity and Child Health Care of Zaozhuang from June 2019 to May 2020 were selected and divided into study group (n=43) and control group (n=43) according to random number table method. The control group was treated with routine therapy, and the study group was treated with low-dose Aspirin on the basis of the control group. The incidence of PE, coagulation function, maternal and infant outcomes and quality of life were compared between the two groups. Result: There was no significant difference in the occurrence time of PE between the two groups (P>0.05). The incidence of PE in the study group (9.30%) was lower than that in the control group (30.23%) (P<0.05). After treatment, prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) in two groups were longer than those before treatment, fibrinogen (FIB) were lower than those before treatment (P<0.05). PT, TT and APTT in the study group were longer than those in the control group, and FIB was lower than that in the control group (P<0.05). The incidence of adverse maternal and infant outcomes in the study group (6.98%) was lower than that in the control group (25.58%) (P<0.05). After treatment, the scores of generic quality of life inventory (GQOLI-74) in both groups were higher than those before treatment, and the scores of GQOLI-74 in the study group were higher than those in the control group (P<0.05). Conclusion: The application of low-dose Aspirin in the treatment of high-risk patients of PE risk prediction can reduce the incidence of PE, improve the body's coagulation function, reduce the incidence of adverse maternal and infant outcomes, and improve the quality of life.

2023 Vol. 20　(26):　131-134 [Abstract]（ 226 ） HTML (1 KB)  PDF  (1176 KB)  ( 74 )

Objective: To evaluate the diagnostic value of combining quantitative parameters of shear wave elastography (SWE) and superb microvascular imaging (SMI) in differentiating papillary thyroid carcinoma (PTC). Method: A total of 88 patients with thyroid nodules who underwent thyroidectomy in the Surgery Department of Tai’an Maternity and Child Health Hospital from January 2020 to October 2022 were selected for this study. All patients received SMI and SWE examination before surgery. The patients were divided into PTC group (n=26) and benign group (n=62) according to the pathological results after surgery. Based on the mean value (Emean), minimum value (Emin), maximum value (Emax), dispersion (SD) of SWE elastic index and blood flow distribution pattern of SMI, the sensitivity, specificity and accuracy of SWE, SMI and combined diagnosis of PTC were analyzed. Result: Emean, Emin, Emax and SD in PTC group were significantly higher than those in benign group (P<0.05). ROC curve analysis showed that SD had the highest AUC in diagnosing PTC, and 53.80% sensitivity, 100% specificity and 86.36% accuracy could be obtained at the cut-off value of 3.52 kPa. SMI detection showed that the blood flow distribution pattern of nodules in benign group was mainly classified as type Ⅱ and type Ⅳ, while nodules in PTC group were mainly classified as type Ⅲ. The sensitivity was 65.38%, specificity was 91.94% and accuracy was 84.09% of SMI in diagnosing PTC alone. The sensitivity was 88.46%, specificity was 93.55% and accuracy was 92.05% of SMI combined with SWE. Conclusion: The combination of SWE quantitative parameters and SMI technology can improve the sensitivity, specificity and accuracy of the diagnosis of PTC, and has good clinical application value.

2023 Vol. 20　(26):　139-143 [Abstract]（ 145 ） HTML (1 KB)  PDF  (1500 KB)  ( 306 )

Objective: To investigate the correlation between polar body morphology of oocyte and fertilization, embryonic development after in vitro fertilization (IVF). Method: From July 2017 to July 2022 in the Assisted Reproduction Department of Maternal and Child Health Hospital of Yichun City, the oocytes at 4-5 h after IVF were divided into group A (second polar body group), group B (broken polar body group), group C (first polar body group) and group D (multipolar body group) according to the polar bodies after degranulation after fertilization. Then the fertilization situation and embryonic development situation of four groups were compared. Result: The total fertilization rate and normal fertilization rate of group A were significantly higher than those of group B, group C and group D, the rates of group B and group D were significantly higher than those of group C; the D3 high-quality embryo rate of group A was significantly higher than those of group B and group C, the D3 high-quality embryo rate of group B was significantly higher than that of group C; the unfertilized rate of group A was significantly lower than those of group B, group C and group D, the rates of group B and group D were significantly lower than that of group C, the differences were statistically significant (P<0.05), the available blastocyst rates of four groups were compared, the differences were not statistically significant (P>0.05). Conclusion: The polar morphology of oocytes after IVF is closely related to fertilization and embryo development, the advantages of second polar body is more prominent, and it is feasible to select embryos by blastocyst culture.

2023 Vol. 20　(26):　147-151 [Abstract]（ 235 ） HTML (1 KB)  PDF  (1587 KB)  ( 81 )

Objective: To explore the relationship between carotid artery low-density plaque and recurrent cerebrovascular events in patients with acute cerebral infarction of carotid artery stenosis based on CT angiography. Method: A total of 86 acute cerebral infarction patients with carotid artery stenosis and low-density plaque confirmed by color ultrasound were selected from May 2020 to May 2021 in Nanchang Hongdu Hospital of TCM. All patients underwent CT angiography and were followed up for 1 year. The relationship between the general clinical data, bad habits, comorbidities, carotid artery low-density plaque information and recurrent cerebrovascular events were analyzed. The influencing factors of early recurrent cerebrovascular events were analyzed by multivariate logistic regression. Result: During 1 year follow up, 26 cases (30.23%) had recurrent cerebrovascular events were set up as the recurrent group, while 60 cases (69.77%) had no recurrent cerebrovascular events were set up as the non-recurrent group. The results of single factor analysis showed that there were statistically significant differences in hypertension, diabetes mellitus, degree of vascular stenosis, plaque length, plaque load, degree of plaque enhancement and intra-plaque bleeding between the two groups (P<0.05). Multivariate logistic regression analysis showed that plaque length [OR=6.630, 95%CI (1.720, 25.575), P=0.006], plaque load [OR=2.748, 95%CI (1.357, 5.568), P=0.005] and plaque enhancement grade 2 [OR=3.271, 95%CI (1.215, 8.804), P=0.019] were independent risk factors of recurrent cerebrovascular events. ROC curve results showed that the combined three risk factors of AUC was 0.965, 95%CI (0.931, 0.999), sensitivity was 100%, specificity was 80.00%. Conclusion: The length, load of carotid artery plaque and plaque enhancement grade 2 are independent risk factors of recurrent cerebrovascular events, CT angiography to observe the characteristics of carotid plaque in patients is of great value in evaluating the incidence of recurrent cerebrovascular events.

2023 Vol. 20　(26):　156-160 [Abstract]（ 214 ） HTML (1 KB)  PDF  (1567 KB)  ( 106 )

Objective: To analyze the correlation between physical and metabolic indexes and serum sirtuin-4 (SIRT4) levels in obesity children, and provide guidance for clinical treatment. Method: A total of 210 children with simple obesity diagnosed and treated in the Department of Endocrinology, Genetics and Metabolism of Jiangxi Provincial Children's Hospital from September 2020 to October 2022 were selected and divided into mild obesity group (n=74), moderate obesity group (n=121) and severe obesity group (n=15) according to body mass index (BMI). Physical indexes [BMI, waist circumference, hip circumference, waist-to-hip ratio (WHR) and skinfold thickness], glucose and lipid metabolism indexes [fasting blood glucose (FBG), insulin resistance index (HOMA-IR), total cholesterol (TC) and triacylglycerol (TG)], SIRT4 levels and growth hormone/insulin-like growth factor 1 (GH/IGF-1) were compared among the three groups. Pearson correlation was used to analyze the correlation between serum SIRT4 level and relevant physical and glucose and lipid metabolism indexes. ROC curve was used to analyze the predictive value of serum SIRT4 level to the degree of obesity in children. Result: There were no significant differences in age, gender, height, WHR, GH/IGF-1 and FBG among the three groups (P>0.05). There were statistically significant differences in physical indexes (BMI, waist circumference, hip circumference and skinfold thickness), glucose and lipid metabolism indexes (HOMA-IR, TC, TG) and serum SIRT4 levels among the three groups (P<0.05), and the levels of physical indexes and glucose and lipid metabolism indexes in the severely obesity group were the highest, while serum SIRT4 level was the lowest. Pearson correlation analysis results showed that the relevant physical indexes, glucose and lipid metabolism indexes were negatively correlated with serum SIRT4 level (P<0.05). ROC curve results showed that the AUC of serum SIRT4 level predicting the outcome of obesity (moderate to severe) was 0.763 (P<0.05). Conclusion: Physical indexes and glucose and lipid metabolism indexes of obesity children are negatively correlated with serum SIRT4 level, and serum SIRT4 level is correlated with the degree of obesity in children.

2023 Vol. 20　(26):　164-168 [Abstract]（ 221 ） HTML (1 KB)  PDF  (1971 KB)  ( 63 )

Objective: To explore the effect of TCM treatment based on syndrome differentiation combined with mindfulness-based stress reduction therapy on survival rate and quality of life of patients with mid-to-advanced liver cancer undergoing interventional therapy. Method: A total of 58 patients with mid-to-advanced liver cancer underwent interventional therpy admitted to the First Affiliated Hospital of Nanchang University from January to July 2021 were selected as the study objects, and were divided into two groups according to random number table method, with 29 cases in each group. Patients in the control group received conventional treatment, and patients in the study group received TCM treatment based on syndrome differentiation combined with mindfulness-based stress reduction therapy on the basis of the control group. TCM syndromes score, mental toughness, cancer-related tiredness, quality of life and 3 and 6 months after treatment of survival rate were compared between the two groups. Result: There were no significant differences in self-rating anxiety scale (SAS), self-rating depression scale (SDS) and cancer-related tiredness scale scores between the two groups before treatment (P>0.05); after treatment, the scores of the above indexes in the study group were lower than those in the control group (P<0.05). After treatment, the scores of TCM symptoms in the study group were lower than those in the control group, and the scores of quality of life in the study group were higher than those in the control group, the differences were statistically significant (P<0.05). The survival rates of the study group at 3 and 6 months after treatment were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion: The application of TCM treatment based on syndrome differentiation combined with mindfulness-based stress reduction therapy in patients with mid-to-advanced liver cancer undergoing interventional therapy can alleviate the uncomfortable symptoms of patients, improve the mental toughness of patients, improve the quality of life and increase the survival rate.

2023 Vol. 20　(26):　174-178 [Abstract]（ 211 ） HTML (1 KB)  PDF  (1396 KB)  ( 231 )

Mild traumatic brain injury (mTBI), commonly known as concussion, is one of the most common neurological disorders, and the mechanisms of brain dysfunction remain unclear. At present, the diagnosis of mTBI depends largely on patients' subjective clinical symptoms, which are often unreliable and/or non-specific. The application of functional magnetic resonance imaging (fMRI) in the evaluation of mTBI makes up for the limitations of traditional structural imaging in the imaging diagnosis of mTBI, provides an objective imaging basis, and makes it possible to understand the interaction between neural network and brain regions in the pathogenesis of mTBI. Task-based fMRI and resting-state fMRI can deeply understand the neuropathological changes after mTBI from different angles, which can more accurately locate the damaged brain functional area, so as to comprehensively evaluate the severity of traumatic brain injury, greatly improve the accuracy of early diagnosis of mTBI, and play an important role in prognosis assessment.

2023 Vol. 20　(26):　185-188 [Abstract]（ 177 ） HTML (1 KB)  PDF  (1370 KB)  ( 190 )